Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review
Cadherin-catenin adhesion complexes play important roles by providing cell-cell adhesion and communication in different organ systems. Abnormal expression of cadherin adhesion molecules constitutes a common phenomenon in canine mammary cancer and has been frequently implicated in tumour progression....
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2012/357187 |
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| _version_ | 1832564226878603264 |
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| author | Adelina Gama Fernando Schmitt |
| author_facet | Adelina Gama Fernando Schmitt |
| author_sort | Adelina Gama |
| collection | DOAJ |
| description | Cadherin-catenin adhesion complexes play important roles by providing cell-cell adhesion and communication in different organ systems. Abnormal expression of cadherin adhesion molecules constitutes a common phenomenon in canine mammary cancer and has been frequently implicated in tumour progression. This paper summarizes the current knowledge on cadherin/catenin adhesion molecules (E-cadherin, β-catenin, and P-cadherin) in canine mammary cancer, focusing on the putative biological functions and clinical significance of these molecules in this disease. This paper highlights the need for further research studies in this setting in order to elucidate the role of these adhesion molecules during tumour progression and metastasis. |
| format | Article |
| id | doaj-art-e44d37b096064373a0f0163eb0bbb795 |
| institution | Kabale University |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-e44d37b096064373a0f0163eb0bbb7952025-02-03T01:11:37ZengWileyVeterinary Medicine International2090-81132042-00482012-01-01201210.1155/2012/357187357187Cadherin Cell Adhesion System in Canine Mammary Cancer: A ReviewAdelina Gama0Fernando Schmitt1Centro de Ciência Animal e Veterinária (CECAV), Universidade de Trás-os-Montes e Alto Douro (UTAD), 5001-911 Vila Real, PortugalInstitute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, PortugalCadherin-catenin adhesion complexes play important roles by providing cell-cell adhesion and communication in different organ systems. Abnormal expression of cadherin adhesion molecules constitutes a common phenomenon in canine mammary cancer and has been frequently implicated in tumour progression. This paper summarizes the current knowledge on cadherin/catenin adhesion molecules (E-cadherin, β-catenin, and P-cadherin) in canine mammary cancer, focusing on the putative biological functions and clinical significance of these molecules in this disease. This paper highlights the need for further research studies in this setting in order to elucidate the role of these adhesion molecules during tumour progression and metastasis.http://dx.doi.org/10.1155/2012/357187 |
| spellingShingle | Adelina Gama Fernando Schmitt Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review Veterinary Medicine International |
| title | Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review |
| title_full | Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review |
| title_fullStr | Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review |
| title_full_unstemmed | Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review |
| title_short | Cadherin Cell Adhesion System in Canine Mammary Cancer: A Review |
| title_sort | cadherin cell adhesion system in canine mammary cancer a review |
| url | http://dx.doi.org/10.1155/2012/357187 |
| work_keys_str_mv | AT adelinagama cadherincelladhesionsystemincaninemammarycancerareview AT fernandoschmitt cadherincelladhesionsystemincaninemammarycancerareview |