NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors
Abstract The potential role of hydrogen sulfide (H2S) in the modulation of neuropathic pain is increasingly recognized. This study investigated the therapeutic effect of intraperitoneal injection of the H2S donor sodium hydrosulfide (NaHS) on neuropathic pain. Utilizing the spared nerve injury (SNI)...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86885-0 |
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| author | Man-Man Qi Heng-Yue Peng Tian-Ge Zhang Yan Li Meng-Ya Gao Wen-Bo Sun Xu-Peng Wang |
| author_facet | Man-Man Qi Heng-Yue Peng Tian-Ge Zhang Yan Li Meng-Ya Gao Wen-Bo Sun Xu-Peng Wang |
| author_sort | Man-Man Qi |
| collection | DOAJ |
| description | Abstract The potential role of hydrogen sulfide (H2S) in the modulation of neuropathic pain is increasingly recognized. This study investigated the therapeutic effect of intraperitoneal injection of the H2S donor sodium hydrosulfide (NaHS) on neuropathic pain. Utilizing the spared nerve injury (SNI) model in mice, the research investigates the role of astrocytes and the excitatory neurotransmitter glutamate in chronic pain. The findings reveal that sodium hydrosulfide (NaHS), an H2S donor, effectively enhances the mechanical pain threshold and thermal pain escape latency in SNI mice. The study further demonstrates NaHS’s potential in reducing glutamate levels in the spinal cord and the discharge frequency of neurons in the primary somatosensory cortex hindlimb region (S1HL) brain area, suggesting a novel therapeutic approach for neuropathic pain through the modulation of astrocyte function and EAAT2 expression. |
| format | Article |
| id | doaj-art-e448a32b61ec45a29f6fe442e2572775 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e448a32b61ec45a29f6fe442e25727752025-01-26T12:28:50ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-86885-0NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviorsMan-Man Qi0Heng-Yue Peng1Tian-Ge Zhang2Yan Li3Meng-Ya Gao4Wen-Bo Sun5Xu-Peng Wang6Department of Anesthesiology, Cangzhou Central HospitalAffiliated Stomatology Hospital of China Medical UniversityDepartment of Anesthesiology, Cangzhou Central HospitalDepartment of Anesthesiology, Cangzhou Central HospitalDepartment of Anesthesiology, Cangzhou Central HospitalDepartment of Anesthesiology, Cangzhou Central HospitalDepartment of Anesthesiology, Cangzhou Central HospitalAbstract The potential role of hydrogen sulfide (H2S) in the modulation of neuropathic pain is increasingly recognized. This study investigated the therapeutic effect of intraperitoneal injection of the H2S donor sodium hydrosulfide (NaHS) on neuropathic pain. Utilizing the spared nerve injury (SNI) model in mice, the research investigates the role of astrocytes and the excitatory neurotransmitter glutamate in chronic pain. The findings reveal that sodium hydrosulfide (NaHS), an H2S donor, effectively enhances the mechanical pain threshold and thermal pain escape latency in SNI mice. The study further demonstrates NaHS’s potential in reducing glutamate levels in the spinal cord and the discharge frequency of neurons in the primary somatosensory cortex hindlimb region (S1HL) brain area, suggesting a novel therapeutic approach for neuropathic pain through the modulation of astrocyte function and EAAT2 expression.https://doi.org/10.1038/s41598-025-86885-0Sodium hydrosulfideNeuropathic painAstrocytesEAAT2 |
| spellingShingle | Man-Man Qi Heng-Yue Peng Tian-Ge Zhang Yan Li Meng-Ya Gao Wen-Bo Sun Xu-Peng Wang NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors Scientific Reports Sodium hydrosulfide Neuropathic pain Astrocytes EAAT2 |
| title | NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors |
| title_full | NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors |
| title_fullStr | NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors |
| title_full_unstemmed | NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors |
| title_short | NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors |
| title_sort | nahs modulates astrocytic eaat2 expression to impact sni induced neuropathic pain and depressive like behaviors |
| topic | Sodium hydrosulfide Neuropathic pain Astrocytes EAAT2 |
| url | https://doi.org/10.1038/s41598-025-86885-0 |
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