Intracranial Gliofibroma: A Case Report and Review of the Literature
Gliofibroma is a rare tumor with biphasic morphology, commonly occurring in the first two decades of life. Currently, the tumor is not listed as a distinct entity in the current World Health Organization (WHO) classification of central nervous system tumors. As its biological behavior, histogenesis,...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/165025 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550385867292672 |
|---|---|
| author | Patricia Gargano Graciela Zuccaro Fabiana Lubieniecki |
| author_facet | Patricia Gargano Graciela Zuccaro Fabiana Lubieniecki |
| author_sort | Patricia Gargano |
| collection | DOAJ |
| description | Gliofibroma is a rare tumor with biphasic morphology, commonly occurring in the first two decades of life. Currently, the tumor is not listed as a distinct entity in the current World Health Organization (WHO) classification of central nervous system tumors. As its biological behavior, histogenesis, and prognostic factors are still debated, the aim of this paper was to describe a case of a gliofibroma and to update the data about these lesions. Hence, we present here clinical symptoms, pathological findings, and evolution observed in a child with gliofibroma. A 10-year-old girl with seizures was referred for study. Neuroimaging showed a hemispheric hyperdense tumor with little peritumoral edema and no mass effect. The tumor was totally removed. Histologically, the tumor consisted of a mixture of glial cells and collagen-rich stroma. Immunohistochemical examination revealed positive staining for GFAP, CD 99, S100, and vimentin. EMA staining showed a paranuclear dot pattern in only few cells in isolated areas. These findings of a glial component with collagenous stroma were consistent with a desmoplastic glioma. Because of the rarity of this entity, we believe it is important to report every case in order to adequately analyze and categorize the tumor in the next WHO classification. |
| format | Article |
| id | doaj-art-e43abe76f46c4ac4a73be00730701874 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-e43abe76f46c4ac4a73be007307018742025-02-03T06:06:57ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/165025165025Intracranial Gliofibroma: A Case Report and Review of the LiteraturePatricia Gargano0Graciela Zuccaro1Fabiana Lubieniecki2Department of Pathology, Garrahan Pediatrics Hospital, Combate de los Pozos 1881, C1245AAM Buenos Aires, ArgentinaDepartment of Neurosurgery, Garrahan Pediatrics Hospital, Combate de los Pozos 1881, C1245AAM Buenos Aires, ArgentinaDepartment of Pathology, Garrahan Pediatrics Hospital, Combate de los Pozos 1881, C1245AAM Buenos Aires, ArgentinaGliofibroma is a rare tumor with biphasic morphology, commonly occurring in the first two decades of life. Currently, the tumor is not listed as a distinct entity in the current World Health Organization (WHO) classification of central nervous system tumors. As its biological behavior, histogenesis, and prognostic factors are still debated, the aim of this paper was to describe a case of a gliofibroma and to update the data about these lesions. Hence, we present here clinical symptoms, pathological findings, and evolution observed in a child with gliofibroma. A 10-year-old girl with seizures was referred for study. Neuroimaging showed a hemispheric hyperdense tumor with little peritumoral edema and no mass effect. The tumor was totally removed. Histologically, the tumor consisted of a mixture of glial cells and collagen-rich stroma. Immunohistochemical examination revealed positive staining for GFAP, CD 99, S100, and vimentin. EMA staining showed a paranuclear dot pattern in only few cells in isolated areas. These findings of a glial component with collagenous stroma were consistent with a desmoplastic glioma. Because of the rarity of this entity, we believe it is important to report every case in order to adequately analyze and categorize the tumor in the next WHO classification.http://dx.doi.org/10.1155/2014/165025 |
| spellingShingle | Patricia Gargano Graciela Zuccaro Fabiana Lubieniecki Intracranial Gliofibroma: A Case Report and Review of the Literature Case Reports in Pathology |
| title | Intracranial Gliofibroma: A Case Report and Review of the Literature |
| title_full | Intracranial Gliofibroma: A Case Report and Review of the Literature |
| title_fullStr | Intracranial Gliofibroma: A Case Report and Review of the Literature |
| title_full_unstemmed | Intracranial Gliofibroma: A Case Report and Review of the Literature |
| title_short | Intracranial Gliofibroma: A Case Report and Review of the Literature |
| title_sort | intracranial gliofibroma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2014/165025 |
| work_keys_str_mv | AT patriciagargano intracranialgliofibromaacasereportandreviewoftheliterature AT gracielazuccaro intracranialgliofibromaacasereportandreviewoftheliterature AT fabianalubieniecki intracranialgliofibromaacasereportandreviewoftheliterature |