CYR61 delivery promotes angiogenesis during bone fracture repair

CYR61 delivery promotes angiogenesis during bone fracture repair

Abstract Compromised vascular supply and insufficient neovascularization impede bone repair, increasing risk of non-union. CYR61, Cysteine-rich angiogenic inducer of 61kD (also known as CCN1), is a matricellular growth factor that has been implicated in fracture repair. Here, we map the distribution...

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Main Authors: Annemarie Lang, Emily A. Eastburn, Mousa Younesi, Madhura P. Nijsure, Carly Siciliano, Annapurna Pranatharthi Haran, Christopher J. Panebianco, Elizabeth Seidl, Rui Tang, Eben Alsberg, Nick J. Willett, Riccardo Gottardi, Dongeun Huh, Joel D. Boerckel
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00398-y
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