Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition

Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition

Abstract Small round cell sarcomas (SRCS) are highly aggressive tumors in soft tissues and bone of mostly children and young adults. Despite being different in many aspects, including genetics, possible cell-of-origin, and pathology, patients with any of these entities all receive the same therapeut...

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Main Authors: Femke C. A. S. Ringnalda, Gijs J. F. van Son, Laurens H. G. Verweij, Seok-Young Kim, Vicky Amo-Addae, Uta E. Flucke, Laura S. Hiemcke–Jiwa, Karin P. S. Langenberg, Jos A. M. Bramer, Lotte Heimans, Michiel A. J. van de Sande, Winan J. van Houdt, Max M. van Noesel, Hinri H. D. Kerstens, Marcel Santoso, Georg Seifert, Olivier Delattre, Katia Scotlandi, Birgit Geoerger, Johannes H. M. Merks, Jan J. Molenaar, Ruben van Boxtel, Marc van de Wetering, Karin Sanders, Hans Clevers
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62673-2
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