Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia

Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia

Abstract The tryptophan (TRP)-kynurenine (KYN) pathway is involved in the pathogenesis of schizophrenia. This study aimed to investigate the levels of TRP-KYN metabolites in serum and urine of patients with first-episode schizophrenia (FES) and their association with clinical manifestations. This st...

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Bibliographic Details
Main Authors: Mian Li, Yue Wu, Yan Xu, Xin Huang, Kerun Gao, Nannan Hu, Shuangyue Zhu, Chengpeng Wang, Sugai Liang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Schizophrenia
Tryptophan-kynurenine pathway
Peripheral metabolites
Neurotoxicity
Neuroprotection
Online Access:https://doi.org/10.1038/s41598-025-86390-4
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