The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer’s disease

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a common neurodegenerative disease, and its pathogenesis is closely associated with neuroinflammation. The control of neuroinflammation in AD is the focus of current research. soluble epoxide hydrolase (sEH) protein is increased in the brain tissues of...

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Bibliographic Details
Main Authors: Xiaowen Sun, Hongxiang Liu, Wei Li, Lin Li, Qian Tian, Qingyang Cao, Yun Meng, Yan Shen, Fengyuan Che, Joanna C. Chiu, Jixu Yu, Bruce D. Hammock
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Inflammation
Subjects:
Alzheimer’s disease
Neuroinflammation
TPPU
Neuroprotection
Drosophila melanogaster
Cell
Online Access:https://doi.org/10.1186/s12950-025-00449-7
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