A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain
Evidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain. Nonsteroid anti-inflammatory drugs (NSAIDs), for example, salicylic acid, aspirin, provided analgesic effects in various types of pain. How...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/752782 |
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| author | Wen-Juan Han Lei Chen Hai-Bo Wang Xiang-Zeng Liu San-Jue Hu Xiao-Li Sun Ceng Luo |
| author_facet | Wen-Juan Han Lei Chen Hai-Bo Wang Xiang-Zeng Liu San-Jue Hu Xiao-Li Sun Ceng Luo |
| author_sort | Wen-Juan Han |
| collection | DOAJ |
| description | Evidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain. Nonsteroid anti-inflammatory drugs (NSAIDs), for example, salicylic acid, aspirin, provided analgesic effects in various types of pain. However, long-term use of these drugs causes unwanted side effects, which limits their implication. Stable nitronyl (NIT) nitroxide radicals have been extensively studied as a unique and interesting class of new antioxidants for protection against oxidative damage. The present study synthesized a novel NIT nitroxide radical with salicylic acid framework (SANR) to provide synergistic effect of both antioxidation and antiinflammation. We demonstrated for the first time that both acute and repeated SANR treatment exerted dramatic analgesic effect in radicular low back pain mimicked by chronic compression of dorsal root ganglion in rats. This analgesic potency was more potent than that produced by classical NSAIDs aspirin and traditional nitroxide radical Tempol alone. Furthermore, SANR-induced behavioral analgesia is found to be mediated, at least in partial, by a reduction of ectopic spontaneous discharges in injured DRG neurons. Therefore, the synthesized NIT nitroxide radical coupling with salicylic acid framework may represent a novel potential therapeutic candidate for treatment of chronic pain, including radicular low back pain. |
| format | Article |
| id | doaj-art-e4037e7fa84d4764b2e640a9591330e6 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e4037e7fa84d4764b2e640a9591330e62025-02-03T00:59:38ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/752782752782A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back PainWen-Juan Han0Lei Chen1Hai-Bo Wang2Xiang-Zeng Liu3San-Jue Hu4Xiao-Li Sun5Ceng Luo6Institute of Neuroscience, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaSchool of Pharmacy, Fourth Military Medical University, Xi’an 710032, ChinaClass 2013, School of Clinical Medicine, Fourth Military Medical University, Xi’an 710032, ChinaInstitute of Neuroscience, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaInstitute of Neuroscience, Fourth Military Medical University, Xi’an 710032, ChinaEvidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain. Nonsteroid anti-inflammatory drugs (NSAIDs), for example, salicylic acid, aspirin, provided analgesic effects in various types of pain. However, long-term use of these drugs causes unwanted side effects, which limits their implication. Stable nitronyl (NIT) nitroxide radicals have been extensively studied as a unique and interesting class of new antioxidants for protection against oxidative damage. The present study synthesized a novel NIT nitroxide radical with salicylic acid framework (SANR) to provide synergistic effect of both antioxidation and antiinflammation. We demonstrated for the first time that both acute and repeated SANR treatment exerted dramatic analgesic effect in radicular low back pain mimicked by chronic compression of dorsal root ganglion in rats. This analgesic potency was more potent than that produced by classical NSAIDs aspirin and traditional nitroxide radical Tempol alone. Furthermore, SANR-induced behavioral analgesia is found to be mediated, at least in partial, by a reduction of ectopic spontaneous discharges in injured DRG neurons. Therefore, the synthesized NIT nitroxide radical coupling with salicylic acid framework may represent a novel potential therapeutic candidate for treatment of chronic pain, including radicular low back pain.http://dx.doi.org/10.1155/2015/752782 |
| spellingShingle | Wen-Juan Han Lei Chen Hai-Bo Wang Xiang-Zeng Liu San-Jue Hu Xiao-Li Sun Ceng Luo A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain Neural Plasticity |
| title | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain |
| title_full | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain |
| title_fullStr | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain |
| title_full_unstemmed | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain |
| title_short | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain |
| title_sort | novel nitronyl nitroxide with salicylic acid framework attenuates pain hypersensitivity and ectopic neuronal discharges in radicular low back pain |
| url | http://dx.doi.org/10.1155/2015/752782 |
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