Plants' Metabolites as Potential Antiobesity Agents
Obesity and obesity-related complications are on the increase both in the developed and developing world. Since existing pharmaceuticals fail to come up with long-term solutions to address this issue, there is an ever-pressing need to find and develop new drugs and alternatives. Natural products, pa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/436039 |
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| _version_ | 1850166589947641856 |
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| author | Najla Gooda Sahib Nazamid Saari Amin Ismail Alfi Khatib Fawzi Mahomoodally Azizah Abdul Hamid |
| author_facet | Najla Gooda Sahib Nazamid Saari Amin Ismail Alfi Khatib Fawzi Mahomoodally Azizah Abdul Hamid |
| author_sort | Najla Gooda Sahib |
| collection | DOAJ |
| description | Obesity and obesity-related complications are on the increase both in the developed and developing world. Since existing pharmaceuticals fail to come up with long-term solutions to address this issue, there is an ever-pressing need to find and develop new drugs and alternatives. Natural products, particularly medicinal plants, are believed to harbor potential antiobesity agents that can act through various mechanisms either by preventing weight gain or promoting weight loss amongst others. The inhibition of key lipid and carbohydrate hydrolyzing and metabolizing enzymes, disruption of adipogenesis, and modulation of its factors or appetite suppression are some of the plethora of targeted approaches to probe the antiobesity potential of medicinal plants. A new technology such as metabolomics, which deals with the study of the whole metabolome, has been identified to be a promising technique to probe the progression of diseases, elucidate their pathologies, and assess the effects of natural health products on certain pathological conditions. This has been applied to drug research, bone health, and to a limited extent to obesity research. This paper thus endeavors to give an overview of those plants, which have been reported to have antiobesity effects and highlight the potential and relevance of metabolomics in obesity research. |
| format | Article |
| id | doaj-art-e3fbf304c07640c8aec64a6d53daa2ba |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e3fbf304c07640c8aec64a6d53daa2ba2025-08-20T02:21:24ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/436039436039Plants' Metabolites as Potential Antiobesity AgentsNajla Gooda Sahib0Nazamid Saari1Amin Ismail2Alfi Khatib3Fawzi Mahomoodally4Azizah Abdul Hamid5Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, 43400 Serdang, MalaysiaFaculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, 43400 Serdang, MalaysiaFaculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, 43400 Serdang, MalaysiaFaculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, 43400 Serdang, MalaysiaDepartment of Health Sciences, Faculty of Science, University of Mauritius, 230 Reduit, MauritiusFaculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, 43400 Serdang, MalaysiaObesity and obesity-related complications are on the increase both in the developed and developing world. Since existing pharmaceuticals fail to come up with long-term solutions to address this issue, there is an ever-pressing need to find and develop new drugs and alternatives. Natural products, particularly medicinal plants, are believed to harbor potential antiobesity agents that can act through various mechanisms either by preventing weight gain or promoting weight loss amongst others. The inhibition of key lipid and carbohydrate hydrolyzing and metabolizing enzymes, disruption of adipogenesis, and modulation of its factors or appetite suppression are some of the plethora of targeted approaches to probe the antiobesity potential of medicinal plants. A new technology such as metabolomics, which deals with the study of the whole metabolome, has been identified to be a promising technique to probe the progression of diseases, elucidate their pathologies, and assess the effects of natural health products on certain pathological conditions. This has been applied to drug research, bone health, and to a limited extent to obesity research. This paper thus endeavors to give an overview of those plants, which have been reported to have antiobesity effects and highlight the potential and relevance of metabolomics in obesity research.http://dx.doi.org/10.1100/2012/436039 |
| spellingShingle | Najla Gooda Sahib Nazamid Saari Amin Ismail Alfi Khatib Fawzi Mahomoodally Azizah Abdul Hamid Plants' Metabolites as Potential Antiobesity Agents The Scientific World Journal |
| title | Plants' Metabolites as Potential Antiobesity Agents |
| title_full | Plants' Metabolites as Potential Antiobesity Agents |
| title_fullStr | Plants' Metabolites as Potential Antiobesity Agents |
| title_full_unstemmed | Plants' Metabolites as Potential Antiobesity Agents |
| title_short | Plants' Metabolites as Potential Antiobesity Agents |
| title_sort | plants metabolites as potential antiobesity agents |
| url | http://dx.doi.org/10.1100/2012/436039 |
| work_keys_str_mv | AT najlagoodasahib plantsmetabolitesaspotentialantiobesityagents AT nazamidsaari plantsmetabolitesaspotentialantiobesityagents AT aminismail plantsmetabolitesaspotentialantiobesityagents AT alfikhatib plantsmetabolitesaspotentialantiobesityagents AT fawzimahomoodally plantsmetabolitesaspotentialantiobesityagents AT azizahabdulhamid plantsmetabolitesaspotentialantiobesityagents |