The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
The altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differe...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/2623317 |
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| _version_ | 1849434725350899712 |
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| author | Changheng Lv Di Yang Donghu Zhang Jiajia Shen Zechen Wang Siyuan He Lingzhang Meng Jian Song Jingjie Zhao |
| author_facet | Changheng Lv Di Yang Donghu Zhang Jiajia Shen Zechen Wang Siyuan He Lingzhang Meng Jian Song Jingjie Zhao |
| author_sort | Changheng Lv |
| collection | DOAJ |
| description | The altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differentially expressed genes in the cancerous biopsies isolated from gastric patients, compared with controls. Among which, ARMCX1 exhibited great potential to serve as a prognostic biomarker for gastric patients; furthermore, patients with low expression of ARMCX1 could be more sensitive to these 9 chemotherapeutic agents: A-770041, AMG-706, ATRA, BEZ235, bortezomib, CGP60474, dasatinib, HG-64-1, and pazopanib, rather than the other chemotherapeutic agents. This study helps the improvement of evaluating the prognosis of gastric cancer patients, and would help optimize chemotherapeutic strategies in consideration of the expression of ARMCX1. |
| format | Article |
| id | doaj-art-e3fae6ecccc740cda708bafd97e7409d |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e3fae6ecccc740cda708bafd97e7409d2025-08-20T03:26:33ZengWileyJournal of Immunology Research2314-71562023-01-01202310.1155/2023/2623317The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences ChemotherapyChangheng Lv0Di Yang1Donghu Zhang2Jiajia Shen3Zechen Wang4Siyuan He5Lingzhang Meng6Jian Song7Jingjie Zhao8Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Department of Pediatric SurgeryCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Life Science and Clinical Research CenterThe altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differentially expressed genes in the cancerous biopsies isolated from gastric patients, compared with controls. Among which, ARMCX1 exhibited great potential to serve as a prognostic biomarker for gastric patients; furthermore, patients with low expression of ARMCX1 could be more sensitive to these 9 chemotherapeutic agents: A-770041, AMG-706, ATRA, BEZ235, bortezomib, CGP60474, dasatinib, HG-64-1, and pazopanib, rather than the other chemotherapeutic agents. This study helps the improvement of evaluating the prognosis of gastric cancer patients, and would help optimize chemotherapeutic strategies in consideration of the expression of ARMCX1.http://dx.doi.org/10.1155/2023/2623317 |
| spellingShingle | Changheng Lv Di Yang Donghu Zhang Jiajia Shen Zechen Wang Siyuan He Lingzhang Meng Jian Song Jingjie Zhao The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy Journal of Immunology Research |
| title | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy |
| title_full | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy |
| title_fullStr | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy |
| title_full_unstemmed | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy |
| title_short | The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy |
| title_sort | expression of armcx1 in gastric cancer contributes to prognosis and influences chemotherapy |
| url | http://dx.doi.org/10.1155/2023/2623317 |
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