Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma
Glaucoma is a chronic and progressive disease, which affects more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of the most common forms of glaucoma. For example, about 2.71 million people in the USA had primary open-angle glaucoma in 2011. Currently POAG is a major cau...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2017-02-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/859 |
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| author | O. V. Saik N. A. Konovalova P. S. Demenkov N. V. Ivanisenko T. V. Ivanisenko D. E. Ivanoshchuk O. S. Konovalova O. A. Podkolodnaya I. N. Lavrik N. A. Kolchanov V. A. Ivanisenko |
| author_facet | O. V. Saik N. A. Konovalova P. S. Demenkov N. V. Ivanisenko T. V. Ivanisenko D. E. Ivanoshchuk O. S. Konovalova O. A. Podkolodnaya I. N. Lavrik N. A. Kolchanov V. A. Ivanisenko |
| author_sort | O. V. Saik |
| collection | DOAJ |
| description | Glaucoma is a chronic and progressive disease, which affects more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of the most common forms of glaucoma. For example, about 2.71 million people in the USA had primary open-angle glaucoma in 2011. Currently POAG is a major cause of irreversible vision loss. In patients with treated open-angle glaucoma the risk of blindness reached to be about 27 %. It is known that the death of optic nerve cells can be triggered by mechanical stress caused by increased intraocular pressure, which induces neuronal apoptosis and is observed in patients with POAG. Currently, there is a large number of scientific publications describing proteins and genes involved in the pathogenesis of POAG, including neuronal apoptosis and the cell response to mechanical stress. However, the molecular- genetic mechanisms underlying the pathophysiology of POAG are still poorly understood. Reconstruction of associative networks describing the functional interactions between these genes/proteins, including biochemical reactions, regulatory interactions, transport, etc., requires the use of methods of automated knowledge extraction from texts of scientific publications. The aim of the work was the analysis of associative networks, describing the molecular-genetic interactions between proteins and genes involved in cell response to mechanical stress (CRMS), neuronal apoptosis and pathogenesis of POAG using ANDSystem, our previous development for automated text analysis. It was shown that genes associated with POAG are statistically significantly more often represented among the genes involved in the interactions between CRMS and neuronal apoptosis than it was expected by random reasons, which can be an explanation for the effect of POAG leading to the retinal ganglion cell death. |
| format | Article |
| id | doaj-art-e3f43e8e01bb42e987fd4651eb705450 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-e3f43e8e01bb42e987fd4651eb7054502025-02-01T09:58:03ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592017-02-0120684084710.18699/VJ16.200548Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucomaO. V. Saik0N. A. Konovalova1P. S. Demenkov2N. V. Ivanisenko3T. V. Ivanisenko4D. E. Ivanoshchuk5O. S. Konovalova6O. A. Podkolodnaya7I. N. Lavrik8N. A. Kolchanov9V. A. Ivanisenko10Institute of Cytology and Genetics SB RASTyumen State Medical UniversityInstitute of Cytology and Genetics SB RASInstitute of Cytology and Genetics SB RAS Novosibirsk State UniversityInstitute of Cytology and Genetics SB RASInstitute of Cytology and Genetics SB RASTyumen State Medical UniversityInstitute of Cytology and Genetics SB RASInstitute of Cytology and Genetics SB RAS Institute of Experimental Internal Medicine, Otto von Guericke UniversityInstitute of Cytology and Genetics SB RASInstitute of Cytology and Genetics SB RASGlaucoma is a chronic and progressive disease, which affects more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of the most common forms of glaucoma. For example, about 2.71 million people in the USA had primary open-angle glaucoma in 2011. Currently POAG is a major cause of irreversible vision loss. In patients with treated open-angle glaucoma the risk of blindness reached to be about 27 %. It is known that the death of optic nerve cells can be triggered by mechanical stress caused by increased intraocular pressure, which induces neuronal apoptosis and is observed in patients with POAG. Currently, there is a large number of scientific publications describing proteins and genes involved in the pathogenesis of POAG, including neuronal apoptosis and the cell response to mechanical stress. However, the molecular- genetic mechanisms underlying the pathophysiology of POAG are still poorly understood. Reconstruction of associative networks describing the functional interactions between these genes/proteins, including biochemical reactions, regulatory interactions, transport, etc., requires the use of methods of automated knowledge extraction from texts of scientific publications. The aim of the work was the analysis of associative networks, describing the molecular-genetic interactions between proteins and genes involved in cell response to mechanical stress (CRMS), neuronal apoptosis and pathogenesis of POAG using ANDSystem, our previous development for automated text analysis. It was shown that genes associated with POAG are statistically significantly more often represented among the genes involved in the interactions between CRMS and neuronal apoptosis than it was expected by random reasons, which can be an explanation for the effect of POAG leading to the retinal ganglion cell death.https://vavilov.elpub.ru/jour/article/view/859apoptosisneuronal apoptosiscell response to mechanical stressprimary open-angle glaucomapoagandsystemassociative gene networks. |
| spellingShingle | O. V. Saik N. A. Konovalova P. S. Demenkov N. V. Ivanisenko T. V. Ivanisenko D. E. Ivanoshchuk O. S. Konovalova O. A. Podkolodnaya I. N. Lavrik N. A. Kolchanov V. A. Ivanisenko Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma Вавиловский журнал генетики и селекции apoptosis neuronal apoptosis cell response to mechanical stress primary open-angle glaucoma poag andsystem associative gene networks. |
| title | Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma |
| title_full | Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma |
| title_fullStr | Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma |
| title_full_unstemmed | Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma |
| title_short | Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma |
| title_sort | molecular genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open angle glaucoma |
| topic | apoptosis neuronal apoptosis cell response to mechanical stress primary open-angle glaucoma poag andsystem associative gene networks. |
| url | https://vavilov.elpub.ru/jour/article/view/859 |
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