Defining occult disease in glioblastoma using spectroscopic MRI: implications for clinical target volume delineation

Defining occult disease in glioblastoma using spectroscopic MRI: implications for clinical target volume delineation

Abstract Background Outcomes in glioblastoma are improved by surgical resection and adjuvant radiation (RT). In primary GBM (pGBM), large clinical target volume (CTV) margins typically cover occult invasion. In recurrent GBM (rGBM), RT often uses tiny CTV margins that likely omit occult invasion due...

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Bibliographic Details
Main Authors: Jonathan B. Bell, Sulaiman Sheriff, Mohammed Z. Goryawala, Kaylie Cullison, Gregory A. Azzam, Jessica Meshman, Matthew C. Abramowitz, Michael E. Ivan, Macarena I. de la Fuente, Eric A. Mellon
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Radiation Oncology
Subjects:
Spectroscopic MRI
Glioblastoma
Online Access:https://doi.org/10.1186/s13014-025-02666-z
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