Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Over the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications. However, with the discovery of enzymes involved in the demethylation process, several exciting prospects have em...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/8764384 |
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| author | Anubhav Chakraborty Pragasam Viswanathan |
| author_facet | Anubhav Chakraborty Pragasam Viswanathan |
| author_sort | Anubhav Chakraborty |
| collection | DOAJ |
| description | Over the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications. However, with the discovery of enzymes involved in the demethylation process, several exciting prospects have emerged that focus on the dynamic regulation of methylation and its crucial role in development and disease. An interplay of the methylation-demethylation machinery controls the process of gene expression. Since acute kidney injury (AKI), a major risk factor for chronic kidney disease and death, is characterised by aberrant expression of genes, understanding the dynamics of methylation and demethylation will provide new insights into the intricacies of the disease. Research on epigenetics in AKI has only made its mark in the recent years but has provided compelling evidence that implicates the involvement of methylation and demethylation changes in its pathophysiology. In this review, we explore the role of methylation and demethylation machinery in cellular epigenetic control and further discuss the contribution of methylomic changes and histone modifications to the pathophysiology of AKI. |
| format | Article |
| id | doaj-art-e3e8482eac864b3fb29b362a561a83d5 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-e3e8482eac864b3fb29b362a561a83d52025-02-03T06:06:52ZengWileyAnalytical Cellular Pathology2210-71772210-71852018-01-01201810.1155/2018/87643848764384Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney InjuryAnubhav Chakraborty0Pragasam Viswanathan1Renal Research Lab, Centre for Bio-Medical Research, School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore 632014, IndiaRenal Research Lab, Centre for Bio-Medical Research, School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore 632014, IndiaOver the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications. However, with the discovery of enzymes involved in the demethylation process, several exciting prospects have emerged that focus on the dynamic regulation of methylation and its crucial role in development and disease. An interplay of the methylation-demethylation machinery controls the process of gene expression. Since acute kidney injury (AKI), a major risk factor for chronic kidney disease and death, is characterised by aberrant expression of genes, understanding the dynamics of methylation and demethylation will provide new insights into the intricacies of the disease. Research on epigenetics in AKI has only made its mark in the recent years but has provided compelling evidence that implicates the involvement of methylation and demethylation changes in its pathophysiology. In this review, we explore the role of methylation and demethylation machinery in cellular epigenetic control and further discuss the contribution of methylomic changes and histone modifications to the pathophysiology of AKI.http://dx.doi.org/10.1155/2018/8764384 |
| spellingShingle | Anubhav Chakraborty Pragasam Viswanathan Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury Analytical Cellular Pathology |
| title | Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury |
| title_full | Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury |
| title_fullStr | Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury |
| title_full_unstemmed | Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury |
| title_short | Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury |
| title_sort | methylation demethylation dynamics implications of changes in acute kidney injury |
| url | http://dx.doi.org/10.1155/2018/8764384 |
| work_keys_str_mv | AT anubhavchakraborty methylationdemethylationdynamicsimplicationsofchangesinacutekidneyinjury AT pragasamviswanathan methylationdemethylationdynamicsimplicationsofchangesinacutekidneyinjury |