Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers
Objective: To compare hematological parameters in iron-deficient and non-deficient carriers of beta thalassemia trait. Study Design And Setting: Comparative cross-sectional study. This study was conducted at the Department of Hematology at PNS SHIFA Hospital, Karachi for six months (February 2023 to...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2024-04-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1424 |
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| author | Nazish Tahir Saeed Akhtar Khan Khattak Ghulam Murtaza Shaikh Zunera Sajjad Tamoor Bin Hanif Nighat Jamal |
| author_facet | Nazish Tahir Saeed Akhtar Khan Khattak Ghulam Murtaza Shaikh Zunera Sajjad Tamoor Bin Hanif Nighat Jamal |
| author_sort | Nazish Tahir |
| collection | DOAJ |
| description | Objective: To compare hematological parameters in iron-deficient and non-deficient carriers of beta thalassemia trait. Study Design And Setting: Comparative cross-sectional study. This study was conducted at the Department of Hematology at PNS SHIFA Hospital, Karachi for six months (February 2023 to July 2023).
Methodology: This comparative cross-sectional study included a total of 304 cases with beta thalassemia trait and was divided into two groups; the Iron-deficient (ID+) and iron-deficient (ID-) group. The study focused on red cell parameters i.e, Hemoglobin (Hb), TRBC, MCV, MCH and RDW. Haemoglobin Electrophoresis results of both groups were also compared. Descriptive statistics were expressed as mean ± SD and the Chi-square test was assigned. A p-value = 0.05 was considered statistically significant.
Results: Out of the total 304 subjects, 76 (25.0%) had iron deficiency, and 228 (75.0) had sufficient iron stores. Mean age of patients was 18 (Range: 3 – 35) years. HbA levels were similar in both the groups with p-value > 0.05. While all other parameters compared showed marked differences among the two groups and were found to be statistically significant. Hb, TRBC, MCV MCH showed lower values in the ID+ group while RDW was lower in the ID- group.
Conclusion: Red Cell parameters and HBA2 levels in beta thalassemia trait vary significantly among the iron deficient vs non-deficient group. Hence due consideration is needed in screening of beta thalassemia trait in patients with iron deficiency anemia. |
| format | Article |
| id | doaj-art-e3e4cfd646df47e09deeb558dc4084a8 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-e3e4cfd646df47e09deeb558dc4084a82025-08-20T03:10:56ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822024-04-01140211311710.51985/JBUMDC20233021424Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient CarriersNazish TahirSaeed Akhtar Khan KhattakGhulam Murtaza ShaikhZunera SajjadTamoor Bin HanifNighat JamalObjective: To compare hematological parameters in iron-deficient and non-deficient carriers of beta thalassemia trait. Study Design And Setting: Comparative cross-sectional study. This study was conducted at the Department of Hematology at PNS SHIFA Hospital, Karachi for six months (February 2023 to July 2023). Methodology: This comparative cross-sectional study included a total of 304 cases with beta thalassemia trait and was divided into two groups; the Iron-deficient (ID+) and iron-deficient (ID-) group. The study focused on red cell parameters i.e, Hemoglobin (Hb), TRBC, MCV, MCH and RDW. Haemoglobin Electrophoresis results of both groups were also compared. Descriptive statistics were expressed as mean ± SD and the Chi-square test was assigned. A p-value = 0.05 was considered statistically significant. Results: Out of the total 304 subjects, 76 (25.0%) had iron deficiency, and 228 (75.0) had sufficient iron stores. Mean age of patients was 18 (Range: 3 – 35) years. HbA levels were similar in both the groups with p-value > 0.05. While all other parameters compared showed marked differences among the two groups and were found to be statistically significant. Hb, TRBC, MCV MCH showed lower values in the ID+ group while RDW was lower in the ID- group. Conclusion: Red Cell parameters and HBA2 levels in beta thalassemia trait vary significantly among the iron deficient vs non-deficient group. Hence due consideration is needed in screening of beta thalassemia trait in patients with iron deficiency anemia.https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1424beta thalassemia, trait, hba2, red cell parameters, iron deficient carriers, iron sufficient carriers. |
| spellingShingle | Nazish Tahir Saeed Akhtar Khan Khattak Ghulam Murtaza Shaikh Zunera Sajjad Tamoor Bin Hanif Nighat Jamal Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers Journal of Bahria University Medical and Dental College beta thalassemia, trait, hba2, red cell parameters, iron deficient carriers, iron sufficient carriers. |
| title | Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers |
| title_full | Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers |
| title_fullStr | Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers |
| title_full_unstemmed | Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers |
| title_short | Red Cell Parameters in Beta Thalassemia Trait; Comparison between Iron Deficient and Non-Deficient Carriers |
| title_sort | red cell parameters in beta thalassemia trait comparison between iron deficient and non deficient carriers |
| topic | beta thalassemia, trait, hba2, red cell parameters, iron deficient carriers, iron sufficient carriers. |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/1424 |
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