The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and is closely associated with metabolic abnormalities. The causes of NAFLD are exceedingly complicated, and it is known that a variety of signaling pathways, endoplasmic reticulum stress, and mitochondrial dys...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535362/full |
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| author | Lihui Zhang Lihui Zhang Lihui Zhang Sutong Liu Sutong Liu Sutong Liu Qing Zhao Xiaoyan Liu Qiang Zhang Minghao Liu Minghao Liu Minghao Liu Wenxiao Zhao Wenxiao Zhao Wenxiao Zhao |
| author_facet | Lihui Zhang Lihui Zhang Lihui Zhang Sutong Liu Sutong Liu Sutong Liu Qing Zhao Xiaoyan Liu Qiang Zhang Minghao Liu Minghao Liu Minghao Liu Wenxiao Zhao Wenxiao Zhao Wenxiao Zhao |
| author_sort | Lihui Zhang |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and is closely associated with metabolic abnormalities. The causes of NAFLD are exceedingly complicated, and it is known that a variety of signaling pathways, endoplasmic reticulum stress, and mitochondrial dysfunction play a role in the pathogenesis of NAFLD. Recent studies have shown that ubiquitination and deubiquitination are involved in the regulation of the NAFLD pathophysiology. Protein ubiquitination is a dynamic and diverse post-translational alteration that affects various cellular biological processes. Numerous disorders, including NAFLD, exhibit imbalances in ubiquitination and deubiquitination. To highlight the significance of this post-translational modification in the pathogenesis of NAFLD and to aid in the development of new therapeutic approaches for the disease, we will discuss the role of enzymes involved in the processes of ubiquitination and deubiquitination, specifically E3 ubiquitin ligases and deubiquitinating enzymes that are important in the regulation of NAFLD. |
| format | Article |
| id | doaj-art-e3dbdb0f384341e8a57c4d4e318e9e35 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e3dbdb0f384341e8a57c4d4e318e9e352025-08-20T03:06:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15353621535362The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver diseaseLihui Zhang0Lihui Zhang1Lihui Zhang2Sutong Liu3Sutong Liu4Sutong Liu5Qing Zhao6Xiaoyan Liu7Qiang Zhang8Minghao Liu9Minghao Liu10Minghao Liu11Wenxiao Zhao12Wenxiao Zhao13Wenxiao Zhao14The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Zhengzhou, Henan, ChinaCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Zhengzhou, Henan, ChinaCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Zhengzhou, Henan, ChinaCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Zhengzhou, Henan, ChinaCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan, ChinaNonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and is closely associated with metabolic abnormalities. The causes of NAFLD are exceedingly complicated, and it is known that a variety of signaling pathways, endoplasmic reticulum stress, and mitochondrial dysfunction play a role in the pathogenesis of NAFLD. Recent studies have shown that ubiquitination and deubiquitination are involved in the regulation of the NAFLD pathophysiology. Protein ubiquitination is a dynamic and diverse post-translational alteration that affects various cellular biological processes. Numerous disorders, including NAFLD, exhibit imbalances in ubiquitination and deubiquitination. To highlight the significance of this post-translational modification in the pathogenesis of NAFLD and to aid in the development of new therapeutic approaches for the disease, we will discuss the role of enzymes involved in the processes of ubiquitination and deubiquitination, specifically E3 ubiquitin ligases and deubiquitinating enzymes that are important in the regulation of NAFLD.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535362/fullubiquitinationdeubiquitinationnon-alcoholic fatty liver diseasepathogenesisresearch progress |
| spellingShingle | Lihui Zhang Lihui Zhang Lihui Zhang Sutong Liu Sutong Liu Sutong Liu Qing Zhao Xiaoyan Liu Qiang Zhang Minghao Liu Minghao Liu Minghao Liu Wenxiao Zhao Wenxiao Zhao Wenxiao Zhao The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease Frontiers in Immunology ubiquitination deubiquitination non-alcoholic fatty liver disease pathogenesis research progress |
| title | The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease |
| title_full | The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease |
| title_fullStr | The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease |
| title_full_unstemmed | The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease |
| title_short | The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease |
| title_sort | role of ubiquitination and deubiquitination in the pathogenesis of non alcoholic fatty liver disease |
| topic | ubiquitination deubiquitination non-alcoholic fatty liver disease pathogenesis research progress |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535362/full |
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