Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity
The current research has involved to develop nanoparticles (NPs) of zinc oxide (ZnO) doped with silver (Ag) through an eco-friendly method. Eclipta prostrate (EP), Eclipta alba (EA), and Tridax procumbans (TP) are subjected to Soxhlet extraction using ethyl acetate. Alkaloids, flavonoids, and phenol...
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Elsevier
2024-12-01
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| Series: | Chemical Physics Impact |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022424003074 |
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| author | Shanmugam K．S Ramkumar Lakshmanan Jagadeesan R Maghimaa M Hemapriya N S. Suresh |
| author_facet | Shanmugam K．S Ramkumar Lakshmanan Jagadeesan R Maghimaa M Hemapriya N S. Suresh |
| author_sort | Shanmugam K．S |
| collection | DOAJ |
| description | The current research has involved to develop nanoparticles (NPs) of zinc oxide (ZnO) doped with silver (Ag) through an eco-friendly method. Eclipta prostrate (EP), Eclipta alba (EA), and Tridax procumbans (TP) are subjected to Soxhlet extraction using ethyl acetate. Alkaloids, flavonoids, and phenols were quantified using standard methods. Polyherbal extract was used to synthesize silver-zinc oxide nanocomposites (Ag-ZnO NCs) via the sol-gel method. The reduction of metal ions was confirmed by UV–visible spectroscopy, scanning electron microscopy, and thermogravimetric analysis. Polyherbal plants are found to have higher concentrations of phenols, flavonoids, and alkaloids than indigenous plants. Ag-ZnO NCs functional group has been identified using Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy. UV–vis spectroscopy revealed the surface plasmon resonance (SPR) of silver nanoparticles at 463–477 nm and zinc oxide nanoparticles at 266–267 nm. For Ag-ZnO NCs, the SPR peak was observed at 450 nm. Scanning electron microscopy confirmed the spherical morphology of the Ag-ZnO NCs. The anti-microbial activity of the formulated Ag-ZnO NCs was more effective than the extract against all tested pathogens. The most effective antimicrobial activities are achieved for Ag-ZnO NCs at 50 µg and 200 µg for extract. Biosynthesized nanoparticles exhibit a significant anti-inflammatory effect of 68% at a low concentration of 500 µg/mL, greater than the efficacy of diclofenac sodium. Additionally, the synthesized Ag-ZnO nanoparticle demonstrated its stability for 90 days and showed strong antimicrobial properties. |
| format | Article |
| id | doaj-art-e3d3bb1ce10f4edc80a2f7108a09ef32 |
| institution | OA Journals |
| issn | 2667-0224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj-art-e3d3bb1ce10f4edc80a2f7108a09ef322025-08-20T02:05:31ZengElsevierChemical Physics Impact2667-02242024-12-01910076310.1016/j.chphi.2024.100763Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activityShanmugam K．S0Ramkumar Lakshmanan1Jagadeesan R2Maghimaa M3Hemapriya N4S. Suresh5Department of Microbiology, K.S.Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Namakkal, Tamil Nadu 637215, India; Corresponding authors.Department of Microbiology, K.S.Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Namakkal, Tamil Nadu 637215, India; Corresponding authors.Department of Horticulture, AnbilDharmalingam Agricultural College and Research Institute, Navalurkuttappattu, Trichy, Tamil Nadu, IndiaCentre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602 105, IndiaCentre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602 105, IndiaCentre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103, IndiaThe current research has involved to develop nanoparticles (NPs) of zinc oxide (ZnO) doped with silver (Ag) through an eco-friendly method. Eclipta prostrate (EP), Eclipta alba (EA), and Tridax procumbans (TP) are subjected to Soxhlet extraction using ethyl acetate. Alkaloids, flavonoids, and phenols were quantified using standard methods. Polyherbal extract was used to synthesize silver-zinc oxide nanocomposites (Ag-ZnO NCs) via the sol-gel method. The reduction of metal ions was confirmed by UV–visible spectroscopy, scanning electron microscopy, and thermogravimetric analysis. Polyherbal plants are found to have higher concentrations of phenols, flavonoids, and alkaloids than indigenous plants. Ag-ZnO NCs functional group has been identified using Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy. UV–vis spectroscopy revealed the surface plasmon resonance (SPR) of silver nanoparticles at 463–477 nm and zinc oxide nanoparticles at 266–267 nm. For Ag-ZnO NCs, the SPR peak was observed at 450 nm. Scanning electron microscopy confirmed the spherical morphology of the Ag-ZnO NCs. The anti-microbial activity of the formulated Ag-ZnO NCs was more effective than the extract against all tested pathogens. The most effective antimicrobial activities are achieved for Ag-ZnO NCs at 50 µg and 200 µg for extract. Biosynthesized nanoparticles exhibit a significant anti-inflammatory effect of 68% at a low concentration of 500 µg/mL, greater than the efficacy of diclofenac sodium. Additionally, the synthesized Ag-ZnO nanoparticle demonstrated its stability for 90 days and showed strong antimicrobial properties.http://www.sciencedirect.com/science/article/pii/S2667022424003074Plant extractNanoparticle synthesisAg-ZnO nanocompositesAntibacterial activityAnti-inflammatory potential |
| spellingShingle | Shanmugam K．S Ramkumar Lakshmanan Jagadeesan R Maghimaa M Hemapriya N S. Suresh Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity Chemical Physics Impact Plant extract Nanoparticle synthesis Ag-ZnO nanocomposites Antibacterial activity Anti-inflammatory potential |
| title | Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity |
| title_full | Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity |
| title_fullStr | Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity |
| title_full_unstemmed | Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity |
| title_short | Green synthesis of bimetallic Ag-ZnO nanocomposite using polyherbal extract for antibacterial and anti-inflammatory activity |
| title_sort | green synthesis of bimetallic ag zno nanocomposite using polyherbal extract for antibacterial and anti inflammatory activity |
| topic | Plant extract Nanoparticle synthesis Ag-ZnO nanocomposites Antibacterial activity Anti-inflammatory potential |
| url | http://www.sciencedirect.com/science/article/pii/S2667022424003074 |
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