Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting

Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting

Abstract Enhancing the sensitivity of radiotherapy (RT) towards renal cell carcinoma (RCC) remains a challenge because RCC is a radioresistant tumor. In this work, we design and report asymmetrically Polyethylene Glycol (PEG)ylated and amphipathic heptamethine indocyanine dyes for efficient radiosen...

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Bibliographic Details
Main Authors: Zifei Wu, Xie Huang, Chuan Wu, Yan Zhou, Mingquan Gao, Shenglin Luo, Qiang Xiang, Weidong Wang, Rong Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Heptamethine
Polyethylene glycol
Cancer theranostics
Radiosensitization
Online Access:https://doi.org/10.1186/s12951-024-03012-3
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