Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study
ObjectiveThis study aims to systematically analyze the epidemiological characteristics, clinical interventions and outcomes of children with acute non-pharmaceutical toxic exposures.MethodsThis retrospective study included all children with acute non-pharmaceutical toxic exposure admitted to the eme...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1510205/full |
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| author | Yanning Qu Rui Tang Zhuyan Duan Mengyi Sheng Hui Wang Shuang Liu Jiao Li Linlin Guo Linying Guo Si Zheng Si Zheng |
| author_facet | Yanning Qu Rui Tang Zhuyan Duan Mengyi Sheng Hui Wang Shuang Liu Jiao Li Linlin Guo Linying Guo Si Zheng Si Zheng |
| author_sort | Yanning Qu |
| collection | DOAJ |
| description | ObjectiveThis study aims to systematically analyze the epidemiological characteristics, clinical interventions and outcomes of children with acute non-pharmaceutical toxic exposures.MethodsThis retrospective study included all children with acute non-pharmaceutical toxic exposure admitted to the emergency department of the Capital Institute of Pediatrics between January 1, 2019, and December 31, 2023. Eligible patients were triaged into red, yellow, and green groups according to their severity condition. Clinical information including demographics, exposure details, clinical manifestation, laboratory results, treatments, and outcomes were extracted from electronic medical records. Univariate and multivariate logistic regression analyses were conducted to identify risk factors associated with hospitalization.ResultsOverall, a total of 718 patients with acute non-pharmaceutical toxic exposures was included in this study, infants and toddlers accounting for 57.9%. The male-to-female ratio was 1.16:1. The majority exposure events occurred at home (89.3%) and in urban settings (78.4%). Accidental poisoning was the predominant cause, accounting for 94.7%, and the primary route of exposure was oral (93.6%). Mercury was the most common exposed substance, representing 18.8% of cases, particularly among preschool-aged children (31.7%). Patients triaged to red zone had a higher proportion of clinical manifestation and required more aggressive treatments. Although most patients discharged without treatment (78.4%), 19.1% need emergency observation, and 2.5% required hospitalization. Logistic regression analysis showed that corrosive household products exposure (OR = 42.747, 95% CI[5.041–362.520]), skin and mucosal damage (OR = 37.052, 95% CI[5.339–257.153]), pesticides exposure (OR = 33.322, 95% CI[3.863–287.423]), heavy metals exposure (OR = 31.636, 95% CI[1.471–680.210]), neurological manifestation (OR = 22.656, 95% CI[4.766–107.711]), positive toxicology results (OR = 15.105, 95% CI[6.584–34.656]), industrial products exposure (OR = 10.294, 95% CI[1.144–92.641]), and intentional poisoning (OR = 3.060, 95% CI[1.733–5.405]) associated with hospitalization.ConclusionPediatric patients exposed to some specific toxicants like industrial products and corrosive household products might associated with a higher risk of severe clinical outcomes. Advocating for enhanced safety regulations or educations and public health initiatives to mitigate the incidence of such exposures is still important for protecting children's health. |
| format | Article |
| id | doaj-art-e3c9e64133ba41ce9beeddc4e2ea999f |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-e3c9e64133ba41ce9beeddc4e2ea999f2025-02-05T12:11:53ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-02-011310.3389/fpubh.2025.15102051510205Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective studyYanning Qu0Rui Tang1Zhuyan Duan2Mengyi Sheng3Hui Wang4Shuang Liu5Jiao Li6Linlin Guo7Linying Guo8Si Zheng9Si Zheng10Department of Critical Care Medicine, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Critical Care Medicine, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaDepartment of Critical Care Medicine, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaDepartment of Critical Care Medicine, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaDepartment of Critical Care Medicine, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaInformation Department, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaDepartment of Critical Care Medicine, Children's Hospital Affiliated to Capital Institute Pediatrics, Beijing, ChinaInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Computer Science and Technology, Institute for Artificial Intelligence, Tsinghua University, Beijing, ChinaObjectiveThis study aims to systematically analyze the epidemiological characteristics, clinical interventions and outcomes of children with acute non-pharmaceutical toxic exposures.MethodsThis retrospective study included all children with acute non-pharmaceutical toxic exposure admitted to the emergency department of the Capital Institute of Pediatrics between January 1, 2019, and December 31, 2023. Eligible patients were triaged into red, yellow, and green groups according to their severity condition. Clinical information including demographics, exposure details, clinical manifestation, laboratory results, treatments, and outcomes were extracted from electronic medical records. Univariate and multivariate logistic regression analyses were conducted to identify risk factors associated with hospitalization.ResultsOverall, a total of 718 patients with acute non-pharmaceutical toxic exposures was included in this study, infants and toddlers accounting for 57.9%. The male-to-female ratio was 1.16:1. The majority exposure events occurred at home (89.3%) and in urban settings (78.4%). Accidental poisoning was the predominant cause, accounting for 94.7%, and the primary route of exposure was oral (93.6%). Mercury was the most common exposed substance, representing 18.8% of cases, particularly among preschool-aged children (31.7%). Patients triaged to red zone had a higher proportion of clinical manifestation and required more aggressive treatments. Although most patients discharged without treatment (78.4%), 19.1% need emergency observation, and 2.5% required hospitalization. Logistic regression analysis showed that corrosive household products exposure (OR = 42.747, 95% CI[5.041–362.520]), skin and mucosal damage (OR = 37.052, 95% CI[5.339–257.153]), pesticides exposure (OR = 33.322, 95% CI[3.863–287.423]), heavy metals exposure (OR = 31.636, 95% CI[1.471–680.210]), neurological manifestation (OR = 22.656, 95% CI[4.766–107.711]), positive toxicology results (OR = 15.105, 95% CI[6.584–34.656]), industrial products exposure (OR = 10.294, 95% CI[1.144–92.641]), and intentional poisoning (OR = 3.060, 95% CI[1.733–5.405]) associated with hospitalization.ConclusionPediatric patients exposed to some specific toxicants like industrial products and corrosive household products might associated with a higher risk of severe clinical outcomes. Advocating for enhanced safety regulations or educations and public health initiatives to mitigate the incidence of such exposures is still important for protecting children's health.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1510205/fullacute non-pharmaceutical toxic exposurechildrenpoisoningcharacteristicsoutcomes |
| spellingShingle | Yanning Qu Rui Tang Zhuyan Duan Mengyi Sheng Hui Wang Shuang Liu Jiao Li Linlin Guo Linying Guo Si Zheng Si Zheng Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study Frontiers in Public Health acute non-pharmaceutical toxic exposure children poisoning characteristics outcomes |
| title | Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study |
| title_full | Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study |
| title_fullStr | Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study |
| title_full_unstemmed | Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study |
| title_short | Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study |
| title_sort | analysis of acute non pharmaceutical toxic exposures in children a 5 year retrospective study |
| topic | acute non-pharmaceutical toxic exposure children poisoning characteristics outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1510205/full |
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