Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta
A total of 15 patients with esthesioneuroblastomas were treated between 1978 and 1992 at the Neurosurgery Department, Nordstadt Hospital, Hannover. In 9 cases, the tumors invaded the anterior cranial fossa. One patient died before any surgical intervention. Eight tumors were operated by a combined p...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
1995-09-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000400005 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166573632847872 |
|---|---|
| author | Marcos Tatagiba Madjid Samii Eva Dankoweit-Timpe Paulo Henrique P. Aguiar Lutz Osterwald Ramesh Babu Helmut Ostertag |
| author_facet | Marcos Tatagiba Madjid Samii Eva Dankoweit-Timpe Paulo Henrique P. Aguiar Lutz Osterwald Ramesh Babu Helmut Ostertag |
| author_sort | Marcos Tatagiba |
| collection | DOAJ |
| description | A total of 15 patients with esthesioneuroblastomas were treated between 1978 and 1992 at the Neurosurgery Department, Nordstadt Hospital, Hannover. In 9 cases, the tumors invaded the anterior cranial fossa. One patient died before any surgical intervention. Eight tumors were operated by a combined paranasal and subfrontal approach. Gross total tumor removal was achieved in all cases. Apart from anosmia, the only postoperative complication was transient mental changes in one case. Immunohistochemical analyses with MIB 1 monoclonal antibodies, directed against recombinant parts of Ki-67 antigen, were performed to estimate the proliferative potential of the esthesioneuroblastomas. Most of the tumors showed high proliferating cell indexes, which ranged from 3 to 42% (mean, 16%). The proliferating cell index with MIB 1 showed a correlation with postoperative outcome, although this was not statistically significant. Esthesioneuroblastomas can be totally removed surgically. The proliferating cell index may reflect histologically the biological behavior of tumor. Long-term follow-up is mandatory, and imunohistochemical studies may be of help in predicting outcome.<br>O índice proliferative celular tumoral de 8 casos cirúrgicos de estesioneuroblastomas com extensão intracraniana (9 com extensão intracraniana em um total de 15, coletados de 1978 a 1992 no Hospital Nordstadt de Hannover, Alemanha) foi avaliado através do anticorpo monoclonal MIB-1, notando -se uma correlação prognostica. A maioria dos tumores revelou índice proliferative) alto (3% a 42%, média de 16%) e a classificação histopatológica de Hyam foi utilizada. A ressecção foi radical em 100% dos casos e o acesso cirúrgico combinado (paranasal e subfrontal) o preconizado. Os autores apresentam revisão da literatura discutindo a sua casuística. |
| format | Article |
| id | doaj-art-e3c09f2d41654ad3a2bca222000c0a36 |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 1995-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e3c09f2d41654ad3a2bca222000c0a362025-08-20T02:21:24ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42271995-09-01533b57758610.1590/S0004-282X1995000400005Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e condutaMarcos TatagibaMadjid SamiiEva Dankoweit-TimpePaulo Henrique P. AguiarLutz OsterwaldRamesh BabuHelmut OstertagA total of 15 patients with esthesioneuroblastomas were treated between 1978 and 1992 at the Neurosurgery Department, Nordstadt Hospital, Hannover. In 9 cases, the tumors invaded the anterior cranial fossa. One patient died before any surgical intervention. Eight tumors were operated by a combined paranasal and subfrontal approach. Gross total tumor removal was achieved in all cases. Apart from anosmia, the only postoperative complication was transient mental changes in one case. Immunohistochemical analyses with MIB 1 monoclonal antibodies, directed against recombinant parts of Ki-67 antigen, were performed to estimate the proliferative potential of the esthesioneuroblastomas. Most of the tumors showed high proliferating cell indexes, which ranged from 3 to 42% (mean, 16%). The proliferating cell index with MIB 1 showed a correlation with postoperative outcome, although this was not statistically significant. Esthesioneuroblastomas can be totally removed surgically. The proliferating cell index may reflect histologically the biological behavior of tumor. Long-term follow-up is mandatory, and imunohistochemical studies may be of help in predicting outcome.<br>O índice proliferative celular tumoral de 8 casos cirúrgicos de estesioneuroblastomas com extensão intracraniana (9 com extensão intracraniana em um total de 15, coletados de 1978 a 1992 no Hospital Nordstadt de Hannover, Alemanha) foi avaliado através do anticorpo monoclonal MIB-1, notando -se uma correlação prognostica. A maioria dos tumores revelou índice proliferative) alto (3% a 42%, média de 16%) e a classificação histopatológica de Hyam foi utilizada. A ressecção foi radical em 100% dos casos e o acesso cirúrgico combinado (paranasal e subfrontal) o preconizado. Os autores apresentam revisão da literatura discutindo a sua casuística.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000400005base craniana anteriorMIB 1neuroblastomanervo olfatórioseios paranasaisradioterapiaanterior cranial baseMIB 1neuroblastomaolfactory nerveparanasal sinusesradiotherapy |
| spellingShingle | Marcos Tatagiba Madjid Samii Eva Dankoweit-Timpe Paulo Henrique P. Aguiar Lutz Osterwald Ramesh Babu Helmut Ostertag Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta Arquivos de Neuro-Psiquiatria base craniana anterior MIB 1 neuroblastoma nervo olfatório seios paranasais radioterapia anterior cranial base MIB 1 neuroblastoma olfactory nerve paranasal sinuses radiotherapy |
| title | Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta |
| title_full | Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta |
| title_fullStr | Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta |
| title_full_unstemmed | Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta |
| title_short | Esthesioneuroblastomas with intracranial extension: proliferative potential and management Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta |
| title_sort | esthesioneuroblastomas with intracranial extension proliferative potential and management estesioneuroblastomas com extensao intracraniana analise do potencial proliferative e conduta |
| topic | base craniana anterior MIB 1 neuroblastoma nervo olfatório seios paranasais radioterapia anterior cranial base MIB 1 neuroblastoma olfactory nerve paranasal sinuses radiotherapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000400005 |
| work_keys_str_mv | AT marcostatagiba esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta AT madjidsamii esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta AT evadankoweittimpe esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta AT paulohenriquepaguiar esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta AT lutzosterwald esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta AT rameshbabu esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta AT helmutostertag esthesioneuroblastomaswithintracranialextensionproliferativepotentialandmanagementestesioneuroblastomascomextensaointracranianaanalisedopotencialproliferativeeconduta |