Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination
There are several challenges in ophthalmology due to the complex physiological structure of eye. In recent years, the field of ophthalmology has witnessed a surge in research exploring the potential of nanomaterials. Nanomaterials are preferred for their biocompatibility and soluble nature, making t...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-09-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.26599/NBE.2024.9290081 |
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| author | Y Santhosh Kumar C. Gurudeva G. Sridevi K. Langeswaran S. Gowtham Kumar |
| author_facet | Y Santhosh Kumar C. Gurudeva G. Sridevi K. Langeswaran S. Gowtham Kumar |
| author_sort | Y Santhosh Kumar |
| collection | DOAJ |
| description | There are several challenges in ophthalmology due to the complex physiological structure of eye. In recent years, the field of ophthalmology has witnessed a surge in research exploring the potential of nanomaterials. Nanomaterials are preferred for their biocompatibility and soluble nature, making them ideal for ophthalmic use. These properties aim to enhance the bioavailability of drugs in this system. We pooled data from various studies using nanotechnology-based formulations to evaluate their influence on ocular drug bioavailability, focusing on AUC as a key metric. A total of 21 studies conducted in different regions of the world were investigated. The investigation determined that nanotechnology-based formulations has a significant potential for improving ocular medications bioavailability. The meta-analysis results indicate that drugs coated with chitosan, chitosan-coated polylactic acid, and lipid carriers exhibit more significant improvement than the drugs without nano carriers. |
| format | Article |
| id | doaj-art-e3b1a6a0ed2e400a8af8356a09bad6db |
| institution | OA Journals |
| issn | 2097-3837 2150-5578 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj-art-e3b1a6a0ed2e400a8af8356a09bad6db2025-08-20T02:13:56ZengTsinghua University PressNano Biomedicine and Engineering2097-38372150-55782024-09-0116351051910.26599/NBE.2024.9290081Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based ExaminationY Santhosh Kumar0C. Gurudeva1G. Sridevi2K. Langeswaran3S. Gowtham Kumar4Faculty of Allied Health Science, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, IndiaKaruna Medical College, Vilayodi, Chittur, Palakkad, Kerala, IndiaDepartment of Physiology, SRM Dental College, Bharathi salai, Chennai, Tamil Nadu, IndiaCancer Informatics Laboratory, Department of Bioinformatics, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, IndiaFaculty of Allied Health Science, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, IndiaThere are several challenges in ophthalmology due to the complex physiological structure of eye. In recent years, the field of ophthalmology has witnessed a surge in research exploring the potential of nanomaterials. Nanomaterials are preferred for their biocompatibility and soluble nature, making them ideal for ophthalmic use. These properties aim to enhance the bioavailability of drugs in this system. We pooled data from various studies using nanotechnology-based formulations to evaluate their influence on ocular drug bioavailability, focusing on AUC as a key metric. A total of 21 studies conducted in different regions of the world were investigated. The investigation determined that nanotechnology-based formulations has a significant potential for improving ocular medications bioavailability. The meta-analysis results indicate that drugs coated with chitosan, chitosan-coated polylactic acid, and lipid carriers exhibit more significant improvement than the drugs without nano carriers.https://www.sciopen.com/article/10.26599/NBE.2024.9290081ocular deliverynanomaterialsbioavailabilityarea under curvechitosanpoly(d,l-lactic acid) (pdlla) |
| spellingShingle | Y Santhosh Kumar C. Gurudeva G. Sridevi K. Langeswaran S. Gowtham Kumar Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination Nano Biomedicine and Engineering ocular delivery nanomaterials bioavailability area under curve chitosan poly(d,l-lactic acid) (pdlla) |
| title | Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination |
| title_full | Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination |
| title_fullStr | Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination |
| title_full_unstemmed | Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination |
| title_short | Nanotechnology’s Impact on Ocular Drug Delivery: A Meta-analysis-based Examination |
| title_sort | nanotechnology s impact on ocular drug delivery a meta analysis based examination |
| topic | ocular delivery nanomaterials bioavailability area under curve chitosan poly(d,l-lactic acid) (pdlla) |
| url | https://www.sciopen.com/article/10.26599/NBE.2024.9290081 |
| work_keys_str_mv | AT ysanthoshkumar nanotechnologysimpactonoculardrugdeliveryametaanalysisbasedexamination AT cgurudeva nanotechnologysimpactonoculardrugdeliveryametaanalysisbasedexamination AT gsridevi nanotechnologysimpactonoculardrugdeliveryametaanalysisbasedexamination AT klangeswaran nanotechnologysimpactonoculardrugdeliveryametaanalysisbasedexamination AT sgowthamkumar nanotechnologysimpactonoculardrugdeliveryametaanalysisbasedexamination |