Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways

ABSTRACT Epilepsy, a chronic neurological disorder affecting around 65 million people globally, is characterized by recurrent, unprovoked epileptic seizures. Psilocin, the active metabolite of psilocybin, a well‐known psychedelic compound, has recently gained attention for its potential antidepressa...

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Main Authors: Mohammad Balabandian, Mohammad Amin Manavi, Ali Lesani, Razieh Mohammad Jafari, Hamed Shafaroodi, Navid Heidari, Javad Mirnajafi‐Zadeh, Alireza Foroumadi, Arya Afrooghe, Ahmad Reza Dehpour
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Pharmacology Research & Perspectives
Subjects:
epilepsy
nitric oxide
psilocin
seizures
serotonin
Online Access:https://doi.org/10.1002/prp2.70079
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