Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer
Chemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). Thus it has been hypothesized that patients with oral cancer and oral potentially malignant le...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2013/813756 |
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| _version_ | 1832558139652702208 |
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| author | Gareema Prasad Michael McCullough |
| author_facet | Gareema Prasad Michael McCullough |
| author_sort | Gareema Prasad |
| collection | DOAJ |
| description | Chemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). Thus it has been hypothesized that patients with oral cancer and oral potentially malignant lesions will have elevated levels of specific chemokines in oral fluids and that this may be used as a marker of both the early detection of malignant disease and progression to malignancy. The concept that salivary biomarkers can be easily measured and indicate disease states has profound consequences for clinical practice and may open up new strategies for the diagnosis, prognosis, and potential therapy of oral squamous cell carcinoma (OSCC). This review focuses on our understanding of cytokines and chemokines and the potential role that they may have in clinical practice. |
| format | Article |
| id | doaj-art-e3abc153041641a58b1f422dce16657e |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-e3abc153041641a58b1f422dce16657e2025-02-03T01:33:12ZengWileyInternational Journal of Dentistry1687-87281687-87362013-01-01201310.1155/2013/813756813756Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral CancerGareema Prasad0Michael McCullough1Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, Parkville, VIC 3010, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, Parkville, VIC 3010, AustraliaChemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). Thus it has been hypothesized that patients with oral cancer and oral potentially malignant lesions will have elevated levels of specific chemokines in oral fluids and that this may be used as a marker of both the early detection of malignant disease and progression to malignancy. The concept that salivary biomarkers can be easily measured and indicate disease states has profound consequences for clinical practice and may open up new strategies for the diagnosis, prognosis, and potential therapy of oral squamous cell carcinoma (OSCC). This review focuses on our understanding of cytokines and chemokines and the potential role that they may have in clinical practice.http://dx.doi.org/10.1155/2013/813756 |
| spellingShingle | Gareema Prasad Michael McCullough Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer International Journal of Dentistry |
| title | Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer |
| title_full | Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer |
| title_fullStr | Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer |
| title_full_unstemmed | Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer |
| title_short | Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer |
| title_sort | chemokines and cytokines as salivary biomarkers for the early diagnosis of oral cancer |
| url | http://dx.doi.org/10.1155/2013/813756 |
| work_keys_str_mv | AT gareemaprasad chemokinesandcytokinesassalivarybiomarkersfortheearlydiagnosisoforalcancer AT michaelmccullough chemokinesandcytokinesassalivarybiomarkersfortheearlydiagnosisoforalcancer |