Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering
Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, and Aaa[D-Arg0,Hyp3...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2014/619373 |
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| _version_ | 1832564299240833024 |
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| author | Dominika Skołuba Dariusz Sobolewski Adam Prahl Edyta Proniewicz |
| author_facet | Dominika Skołuba Dariusz Sobolewski Adam Prahl Edyta Proniewicz |
| author_sort | Dominika Skołuba |
| collection | DOAJ |
| description | Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, and Aaa[D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, were deposited onto colloidal Au particles of 20 nm size. Interaction of these molecules with colloidal Au surface was explored by surface-enhanced Raman scattering (SERS). Briefly, it was shown that BK adsorbs on the Au surface mainly through the Phe5/Phe8 residues. In case of the BK specifically modified analogues mainly the Pip and Thi rings are involved in the interaction process; however, Pip and Thi adopt slightly different orientation with respect to Au for each of the analogues. In addition, the lack of the Aaa vibrations, together with the enhancement of the Thi, Pip, or Phe modes, emphasizes the importance of the C-terminus in the interaction with the Au surface. |
| format | Article |
| id | doaj-art-e3a2e354726c4c41b1c74efa316d76bc |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-e3a2e354726c4c41b1c74efa316d76bc2025-02-03T01:11:20ZengWileyJournal of Spectroscopy2314-49202314-49392014-01-01201410.1155/2014/619373619373Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman ScatteringDominika Skołuba0Dariusz Sobolewski1Adam Prahl2Edyta Proniewicz3Faculty of Chemistry, Jagiellonian University, Ulica Ingardena 3, 30-060 Krakow, PolandDepartment of Chemistry, University of Gdansk, Sobieskiego 18, 80-592 Gdansk, PolandDepartment of Chemistry, University of Gdansk, Sobieskiego 18, 80-592 Gdansk, PolandFaculty of Foundry Engineering, AGH University of Science and Technology, ul. Reymonta 23, 30-059 Krakow, PolandBradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, and Aaa[D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, were deposited onto colloidal Au particles of 20 nm size. Interaction of these molecules with colloidal Au surface was explored by surface-enhanced Raman scattering (SERS). Briefly, it was shown that BK adsorbs on the Au surface mainly through the Phe5/Phe8 residues. In case of the BK specifically modified analogues mainly the Pip and Thi rings are involved in the interaction process; however, Pip and Thi adopt slightly different orientation with respect to Au for each of the analogues. In addition, the lack of the Aaa vibrations, together with the enhancement of the Thi, Pip, or Phe modes, emphasizes the importance of the C-terminus in the interaction with the Au surface.http://dx.doi.org/10.1155/2014/619373 |
| spellingShingle | Dominika Skołuba Dariusz Sobolewski Adam Prahl Edyta Proniewicz Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering Journal of Spectroscopy |
| title | Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering |
| title_full | Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering |
| title_fullStr | Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering |
| title_full_unstemmed | Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering |
| title_short | Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering |
| title_sort | interaction of bradykinin and b2 bradykinin receptor antagonists with colloidal au surface explored by surface enhanced raman scattering |
| url | http://dx.doi.org/10.1155/2014/619373 |
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