Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease
Abstract Background Coronary heart disease (CHD) is a chronic inflammatory disease carrying high morbidity and mortality. Interleukin (IL)-29 may be used as a biomarker for autoimmune diseases. This paper investigates the diagnostic value of serum IL-29 in CHD patients. Methods A total of 90 CHD pat...
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BMC
2025-05-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-025-03490-y |
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| author | Ping Ni Liming Dai Hai Li Jun Sun Yicheng Zhu Xiaolei Lv |
| author_facet | Ping Ni Liming Dai Hai Li Jun Sun Yicheng Zhu Xiaolei Lv |
| author_sort | Ping Ni |
| collection | DOAJ |
| description | Abstract Background Coronary heart disease (CHD) is a chronic inflammatory disease carrying high morbidity and mortality. Interleukin (IL)-29 may be used as a biomarker for autoimmune diseases. This paper investigates the diagnostic value of serum IL-29 in CHD patients. Methods A total of 90 CHD patients (39 mild and 51 severe patients) and 90 controls were included. Serum IL-29 levels were detected by ELISA, and the diagnostic value of IL-29 in CHD was analyzed by ROC curve. According to the median value of serum IL-29 level, CHD patients were categorized into IL-29 low-level group and high-level group. The correlation between IL-29 and pathological indexes of CHD patients was analyzed by chi-square test. SYNTAX score was used to classify CHD patients into mild CHD and moderate/severe CHD. Pearson coefficient analyzed the correlation between IL-29 and CHD severity. Multivariate logistic regression analyzed the risk factors for CHD exacerbation. Results IL-29 serum levels were elevated in CHD patients. The AUC for CHD diagnosis by serum IL-29 was 0.789 (65.6% sensitivity and 76.7% specificity). IL-29 was correlated with BMI, PHASE score, and CRP. IL-29 serum level was positively correlated with CHD severity. The AUC for differentiating mild and moderate/severe CHD patients by IL-29 level was 0.739 (70.6% sensitivity and 66.7% specificity). IL-29 was an independent risk factor for CHD exacerbation, and each one-unit increase in IL-29 increased the risk of exacerbation in CHD patients by 1.065-fold. Conclusion IL-29 is highly expressed in CHD patients and has auxiliary diagnostic value for CHD. |
| format | Article |
| id | doaj-art-e393b558bc1c43f0a61a3ad7c831ddbe |
| institution | OA Journals |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-e393b558bc1c43f0a61a3ad7c831ddbe2025-08-20T02:03:39ZengBMCJournal of Cardiothoracic Surgery1749-80902025-05-012011710.1186/s13019-025-03490-yExpression level and clinical significance of IL-29 in serum of patients with coronary heart diseasePing Ni0Liming Dai1Hai Li2Jun Sun3Yicheng Zhu4Xiaolei Lv5Department of Cardiology, The Third People’s Hospital of KunshanDepartment of Cardiology, The Third People’s Hospital of KunshanDepartment of Cardiology, The Third People’s Hospital of KunshanDepartment of Cardiology, The Third People’s Hospital of KunshanDepartment of Cardiology, The Third People’s Hospital of KunshanDepartment of Cardiology, The First People’s Hospital of KunshanAbstract Background Coronary heart disease (CHD) is a chronic inflammatory disease carrying high morbidity and mortality. Interleukin (IL)-29 may be used as a biomarker for autoimmune diseases. This paper investigates the diagnostic value of serum IL-29 in CHD patients. Methods A total of 90 CHD patients (39 mild and 51 severe patients) and 90 controls were included. Serum IL-29 levels were detected by ELISA, and the diagnostic value of IL-29 in CHD was analyzed by ROC curve. According to the median value of serum IL-29 level, CHD patients were categorized into IL-29 low-level group and high-level group. The correlation between IL-29 and pathological indexes of CHD patients was analyzed by chi-square test. SYNTAX score was used to classify CHD patients into mild CHD and moderate/severe CHD. Pearson coefficient analyzed the correlation between IL-29 and CHD severity. Multivariate logistic regression analyzed the risk factors for CHD exacerbation. Results IL-29 serum levels were elevated in CHD patients. The AUC for CHD diagnosis by serum IL-29 was 0.789 (65.6% sensitivity and 76.7% specificity). IL-29 was correlated with BMI, PHASE score, and CRP. IL-29 serum level was positively correlated with CHD severity. The AUC for differentiating mild and moderate/severe CHD patients by IL-29 level was 0.739 (70.6% sensitivity and 66.7% specificity). IL-29 was an independent risk factor for CHD exacerbation, and each one-unit increase in IL-29 increased the risk of exacerbation in CHD patients by 1.065-fold. Conclusion IL-29 is highly expressed in CHD patients and has auxiliary diagnostic value for CHD.https://doi.org/10.1186/s13019-025-03490-yCoronary heart diseaseIL-29DiagnosisROCLogistic regressionSYNTAX score |
| spellingShingle | Ping Ni Liming Dai Hai Li Jun Sun Yicheng Zhu Xiaolei Lv Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease Journal of Cardiothoracic Surgery Coronary heart disease IL-29 Diagnosis ROC Logistic regression SYNTAX score |
| title | Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease |
| title_full | Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease |
| title_fullStr | Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease |
| title_full_unstemmed | Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease |
| title_short | Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease |
| title_sort | expression level and clinical significance of il 29 in serum of patients with coronary heart disease |
| topic | Coronary heart disease IL-29 Diagnosis ROC Logistic regression SYNTAX score |
| url | https://doi.org/10.1186/s13019-025-03490-y |
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