Osteoporosis in Rett Syndrome: A Study on Normal Values
Osteoporosis is the reduction of calcium density in bones, usually evident in postmenopausal females, yet the tendency for osteoporosis can also be identified at a young age, especially in patients with chronic diseases, disabilities, and on chronic anticonvalsant treatment. Individuals with Rett sy...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.266 |
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| _version_ | 1832551640936218624 |
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| author | Lilit Zysman Meir Lotan Bruria Ben-Zeev |
| author_facet | Lilit Zysman Meir Lotan Bruria Ben-Zeev |
| author_sort | Lilit Zysman |
| collection | DOAJ |
| description | Osteoporosis is the reduction of calcium density in bones, usually evident in postmenopausal females, yet the tendency for osteoporosis can also be identified at a young age, especially in patients with chronic diseases, disabilities, and on chronic anticonvalsant treatment. Individuals with Rett syndrome (RS) have been found to show signs of osteoporosis at a young age. This condition may cause pathological fractures, inflict pain, and seriously damage mobility. In such cases, the quality of life of the individual and her primary caretakers will be severely hampered. This article reviews the current knowledge of the phenomenon and suggests some clinical directions for the individual with RS who shows signs of osteoporosis. The article also presents novel findings from a screening test of bone strength in 35 individuals with RS at different ages using the Sunlight Omnisense 7000P ultrasound apparatus. The primary results from this investigation showed a strong and significant positive correlation between calcium intake and bone strength (p < 0.0001) as well as bone density Z values (p < 0.005). The occurrence and frequency of fractures were found connected with reduced bone strength in measurements of both the radius (p < 0.0001) and the tibia (p < 0.004) as well as with negative bone strength Z values (p = 0.03). Other findings specified within the content of the article support the implementation of a comprehensive antiosteoporotic preventive management for this population. |
| format | Article |
| id | doaj-art-e38cb4f1a20a4efb9681c4cfbcfce3c3 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e38cb4f1a20a4efb9681c4cfbcfce3c32025-02-03T06:00:59ZengWileyThe Scientific World Journal1537-744X2006-01-0161619163010.1100/tsw.2006.266Osteoporosis in Rett Syndrome: A Study on Normal ValuesLilit Zysman0Meir Lotan1Bruria Ben-Zeev2National Evaluation Team, Israel Rett Syndrome Center Chaim Sheba Medical Center, Tel HaShomer, Ramat Gan, IsraelNational Evaluation Team, Israel Rett Syndrome Center Chaim Sheba Medical Center, Tel HaShomer, Ramat Gan, IsraelNational Evaluation Team, Israel Rett Syndrome Center Chaim Sheba Medical Center, Tel HaShomer, Ramat Gan, IsraelOsteoporosis is the reduction of calcium density in bones, usually evident in postmenopausal females, yet the tendency for osteoporosis can also be identified at a young age, especially in patients with chronic diseases, disabilities, and on chronic anticonvalsant treatment. Individuals with Rett syndrome (RS) have been found to show signs of osteoporosis at a young age. This condition may cause pathological fractures, inflict pain, and seriously damage mobility. In such cases, the quality of life of the individual and her primary caretakers will be severely hampered. This article reviews the current knowledge of the phenomenon and suggests some clinical directions for the individual with RS who shows signs of osteoporosis. The article also presents novel findings from a screening test of bone strength in 35 individuals with RS at different ages using the Sunlight Omnisense 7000P ultrasound apparatus. The primary results from this investigation showed a strong and significant positive correlation between calcium intake and bone strength (p < 0.0001) as well as bone density Z values (p < 0.005). The occurrence and frequency of fractures were found connected with reduced bone strength in measurements of both the radius (p < 0.0001) and the tibia (p < 0.004) as well as with negative bone strength Z values (p = 0.03). Other findings specified within the content of the article support the implementation of a comprehensive antiosteoporotic preventive management for this population.http://dx.doi.org/10.1100/tsw.2006.266 |
| spellingShingle | Lilit Zysman Meir Lotan Bruria Ben-Zeev Osteoporosis in Rett Syndrome: A Study on Normal Values The Scientific World Journal |
| title | Osteoporosis in Rett Syndrome: A Study on Normal Values |
| title_full | Osteoporosis in Rett Syndrome: A Study on Normal Values |
| title_fullStr | Osteoporosis in Rett Syndrome: A Study on Normal Values |
| title_full_unstemmed | Osteoporosis in Rett Syndrome: A Study on Normal Values |
| title_short | Osteoporosis in Rett Syndrome: A Study on Normal Values |
| title_sort | osteoporosis in rett syndrome a study on normal values |
| url | http://dx.doi.org/10.1100/tsw.2006.266 |
| work_keys_str_mv | AT lilitzysman osteoporosisinrettsyndromeastudyonnormalvalues AT meirlotan osteoporosisinrettsyndromeastudyonnormalvalues AT bruriabenzeev osteoporosisinrettsyndromeastudyonnormalvalues |