Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye
Purpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigat...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2010/206837 |
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| author | Shigeru Honda Takayuki Nagai Naoshi Kondo Masahide Fukuda Sentaro Kusuhara Yasutomo Tsukahara Akira Negi |
| author_facet | Shigeru Honda Takayuki Nagai Naoshi Kondo Masahide Fukuda Sentaro Kusuhara Yasutomo Tsukahara Akira Negi |
| author_sort | Shigeru Honda |
| collection | DOAJ |
| description | Purpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigate the therapeutic effects of oral bisphosphonates for CNV in humans. Methods. Thirty-six consecutive cases with CNV due to AMD or PM who declined anti-VEGF therapy were recruited. The patients were prescribed 5 mg of oral alendronates daily for 6 months. The best-corrected visual-acuity (BCVA), the lesion size in fundus photographs and fluorescein angiography, foveal thickness and total macular volume in optical coherence tomography were compared between pre- and post-treatment. Results. The mean BCVA of the patients was significantly improved after a months with the treatment in the AMD group. In the PM group, the mean BCVA was maintained up to 6 months with the treatment. The mean lesion size was significantly decreased by 3 months in both groups. The averages of foveal thickness and total macular volume were significantly reduced after 1 month of treatment in the AMD group.Conclusions. Oral bisphosphonate should be further investigated as a possible therapeutic and preventive drug for CNV due to AMD and PM. |
| format | Article |
| id | doaj-art-e38689b09f9f4b969b86dcaddc27b8a3 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-e38689b09f9f4b969b86dcaddc27b8a32025-02-03T05:58:37ZengWileyJournal of Ophthalmology2090-004X2090-00582010-01-01201010.1155/2010/206837206837Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human EyeShigeru Honda0Takayuki Nagai1Naoshi Kondo2Masahide Fukuda3Sentaro Kusuhara4Yasutomo Tsukahara5Akira Negi6Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 650-0017, JapanPurpose. Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported to have anti-angiogenic effects. The purpose of this study is to investigate the therapeutic effects of oral bisphosphonates for CNV in humans. Methods. Thirty-six consecutive cases with CNV due to AMD or PM who declined anti-VEGF therapy were recruited. The patients were prescribed 5 mg of oral alendronates daily for 6 months. The best-corrected visual-acuity (BCVA), the lesion size in fundus photographs and fluorescein angiography, foveal thickness and total macular volume in optical coherence tomography were compared between pre- and post-treatment. Results. The mean BCVA of the patients was significantly improved after a months with the treatment in the AMD group. In the PM group, the mean BCVA was maintained up to 6 months with the treatment. The mean lesion size was significantly decreased by 3 months in both groups. The averages of foveal thickness and total macular volume were significantly reduced after 1 month of treatment in the AMD group.Conclusions. Oral bisphosphonate should be further investigated as a possible therapeutic and preventive drug for CNV due to AMD and PM.http://dx.doi.org/10.1155/2010/206837 |
| spellingShingle | Shigeru Honda Takayuki Nagai Naoshi Kondo Masahide Fukuda Sentaro Kusuhara Yasutomo Tsukahara Akira Negi Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye Journal of Ophthalmology |
| title | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
| title_full | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
| title_fullStr | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
| title_full_unstemmed | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
| title_short | Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye |
| title_sort | therapeutic effect of oral bisphosphonates on choroidal neovascularization in the human eye |
| url | http://dx.doi.org/10.1155/2010/206837 |
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