Interleukin-1 Modulation of Human Placental Trophoblast Proliferation
<p>During early pregnancy, interleukin-1 (IL-1) is mainly produced and secreted by maternal decidua. Yet, its biological function on placental cells is not well defined. In this study, we employed JAR choriocarcinoma cell line as a model of human placental trophoblast to study the effect of IL...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/79359 |
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| Summary: | <p>During early pregnancy, interleukin-1 (IL-1) is mainly produced and secreted by maternal decidua. Yet, its biological function on placental cells is not well defined. In this study, we employed JAR choriocarcinoma cell line as a model of human placental trophoblast to study the effect of IL-1. Treatment with recombinant human IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> resulted in significant inhibition of JAR proliferation (<mml:math alttext="$P<.05$"> <mml:mrow> <mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.05</mml:mn> </mml:mrow> </mml:math>) paralleled with increased cytotoxicity. The inhibitory effect was blocked by both IL-1 receptor antagonist (IL-1Ra) and antihuman IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> monoclonal antibody. Analyzing the mode of action, IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> was found to induce cell cycle arrest in the G0/G1 phase and triggered apoptotic cell death. These findings demonstrated that IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death.</p> |
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| ISSN: | 0962-9351 |