Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis
Objective: to evaluate the efficiency of basic therapy for rheumatoid arthritis (RA) depending on the time of its start and the choice of a starting regimen. Subjects and methods. The study included 258 patients with verified RA, who were divided into groups by the time of basic therapy initiation....
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2010-12-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/318 |
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| _version_ | 1849690427675901952 |
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| author | Irina Mikhailovna Marusenko |
| author_facet | Irina Mikhailovna Marusenko |
| author_sort | Irina Mikhailovna Marusenko |
| collection | DOAJ |
| description | Objective: to evaluate the efficiency of basic therapy for rheumatoid arthritis (RA) depending on the time of its start and the choice of a starting regimen. Subjects and methods. The study included 258 patients with verified RA, who were divided into groups by the time of basic therapy initiation. All the patients were estimated for changes in the articular syndrome (Ritchie articular index, the number of painful joints, that of inflamed joints, pain and total disease activity assessment by the visual analogue scale, morning stiffness in minutes, and the number of erosions by hand and foot X-ray films). Therapeutic effectiveness was evaluated by the EULAR criteria on the basis of DAS 4 changes and the number of erosions. Results. The study group showed significant clinical and laboratory improvements at the early start of basic therapy as compared with the controls. Assessment using the EURLAR criteria indicated better short-term results in leflunomide-treated patients; overall, a greater percentage of improvements were noted in the study group than in the control one. The study group exhibited a total significantly less increase in the number of erosions as did subgroups with different basic therapy options, but not the sulfasalazine subgroup. Conclusion. Basic therapy initiated at the time of diagnosis of RA permits disease activity and progression to be more effectively controlled than delayed therapy |
| format | Article |
| id | doaj-art-e383388a2815434cb8cd2661ba5d4934 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2010-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-e383388a2815434cb8cd2661ba5d49342025-08-20T03:21:18ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2010-12-0144323910.14412/1996-7012-2010-6331623Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritisIrina Mikhailovna MarusenkoObjective: to evaluate the efficiency of basic therapy for rheumatoid arthritis (RA) depending on the time of its start and the choice of a starting regimen. Subjects and methods. The study included 258 patients with verified RA, who were divided into groups by the time of basic therapy initiation. All the patients were estimated for changes in the articular syndrome (Ritchie articular index, the number of painful joints, that of inflamed joints, pain and total disease activity assessment by the visual analogue scale, morning stiffness in minutes, and the number of erosions by hand and foot X-ray films). Therapeutic effectiveness was evaluated by the EULAR criteria on the basis of DAS 4 changes and the number of erosions. Results. The study group showed significant clinical and laboratory improvements at the early start of basic therapy as compared with the controls. Assessment using the EURLAR criteria indicated better short-term results in leflunomide-treated patients; overall, a greater percentage of improvements were noted in the study group than in the control one. The study group exhibited a total significantly less increase in the number of erosions as did subgroups with different basic therapy options, but not the sulfasalazine subgroup. Conclusion. Basic therapy initiated at the time of diagnosis of RA permits disease activity and progression to be more effectively controlled than delayed therapyhttps://mrj.ima-press.net/mrj/article/view/318rheumatoid arthritisbasic anti-inflammatory drugs |
| spellingShingle | Irina Mikhailovna Marusenko Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis Современная ревматология rheumatoid arthritis basic anti-inflammatory drugs |
| title | Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis |
| title_full | Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis |
| title_fullStr | Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis |
| title_full_unstemmed | Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis |
| title_short | Evaluation of the efficacy of standard basic anti-inflammatory drugs and the time to start basictherapy for rheumatoid arthritis |
| title_sort | evaluation of the efficacy of standard basic anti inflammatory drugs and the time to start basictherapy for rheumatoid arthritis |
| topic | rheumatoid arthritis basic anti-inflammatory drugs |
| url | https://mrj.ima-press.net/mrj/article/view/318 |
| work_keys_str_mv | AT irinamikhailovnamarusenko evaluationoftheefficacyofstandardbasicantiinflammatorydrugsandthetimetostartbasictherapyforrheumatoidarthritis |