Blocking cancer-fibroblast mutualism inhibits proliferation of endocrine therapy resistant breast cancer

Blocking cancer-fibroblast mutualism inhibits proliferation of endocrine therapy resistant breast cancer

Abstract In early-stage estrogen receptor-positive (ER + ) breast cancer, resistance to endocrine therapy (ET) and CDK4/6 inhibitors (CDK4/6i) often involve a shift away from estrogen-driven proliferation. The nature and source of compensatory growth signals driving cancer proliferation remain unkno...

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Bibliographic Details
Main Authors: Jason I Griffiths, Feng Chi, Elena Farmaki, Eric F Medina, Patrick A Cosgrove, Kimya L Karimi, Jinfeng Chen, Vince K Grolmusz, Frederick R Adler, Qamar J Khan, Aritro Nath, Jeffrey T Chang, Andrea H Bild
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:Molecular Systems Biology
Subjects:
Endocrine Resistance
Cancer-fibroblast-mutualism
ERBB Signaling
TME-communication
Online Access:https://doi.org/10.1038/s44320-025-00104-6
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