Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients
A severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyze...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/16492 |
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| _version_ | 1832567205063032832 |
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| author | Y. Kenan Coban Murat Aral |
| author_facet | Y. Kenan Coban Murat Aral |
| author_sort | Y. Kenan Coban |
| collection | DOAJ |
| description | A severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. Serum samples were taken at admission at the 48th hour of postburn. IL-6, IL-18, and TNF-α serum levels were analyzed. Total mean burned surface area (TBSA) was 24.6±5.7% and mean BMI (body mass index) was 24.5±3.4. The patients' age ranged from 17 to 38 (mean 26.3±7.4) years. An increase in sera
IL-6, IL-18, and TNF-α was detected at the 48th hour postburn (P<.0001). All patients survived. A marked increase in serum levels of IL-18 as well as the other cytokines evaluated was observed in the moderately burned patients. These three parameters were highly correlated with each other (r>0.9 and P<.001). This is the first study that shows an increase in serum IL-18 levels at the early postburn period. |
| format | Article |
| id | doaj-art-e376d20dd9c041bdbf596c584af11fbe |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e376d20dd9c041bdbf596c584af11fbe2025-02-03T01:02:10ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/1649216492Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned PatientsY. Kenan Coban0Murat Aral1Department of Plastic Surgery, School of Medicine, Sutcu Imam University, Kahramanmaras 46100, TurkeyDepartment of Microbiology and Immunology, School of Medicine, Sutcu Imam University, Kahramanmaras 46100, TurkeyA severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. Serum samples were taken at admission at the 48th hour of postburn. IL-6, IL-18, and TNF-α serum levels were analyzed. Total mean burned surface area (TBSA) was 24.6±5.7% and mean BMI (body mass index) was 24.5±3.4. The patients' age ranged from 17 to 38 (mean 26.3±7.4) years. An increase in sera IL-6, IL-18, and TNF-α was detected at the 48th hour postburn (P<.0001). All patients survived. A marked increase in serum levels of IL-18 as well as the other cytokines evaluated was observed in the moderately burned patients. These three parameters were highly correlated with each other (r>0.9 and P<.001). This is the first study that shows an increase in serum IL-18 levels at the early postburn period.http://dx.doi.org/10.1155/MI/2006/16492 |
| spellingShingle | Y. Kenan Coban Murat Aral Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients Mediators of Inflammation |
| title | Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients |
| title_full | Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients |
| title_fullStr | Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients |
| title_full_unstemmed | Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients |
| title_short | Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients |
| title_sort | serum il 18 is increased at early postburn period in moderately burned patients |
| url | http://dx.doi.org/10.1155/MI/2006/16492 |
| work_keys_str_mv | AT ykenancoban serumil18isincreasedatearlypostburnperiodinmoderatelyburnedpatients AT murataral serumil18isincreasedatearlypostburnperiodinmoderatelyburnedpatients |