The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review

The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review

Apolipoprotein E (APOE) alleles play distinct roles in the pathogenesis of Alzheimer’s disease (AD), with <i>APOE</i>ε4 being the strongest genetic risk factor for late-onset AD, while <i>APOE</i>ε2 appears protective. Despite extensive research, the precise mechanisms by whi...

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Bibliographic Details
Main Authors: Aiwei Liu, Tingxu Wang, Liu Yang, Yu Zhou
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Brain Sciences
Subjects:
Alzheimer’s disease
apolipoprotein E
microglia
inflammation
phagocytosis
lipid metabolism
Online Access:https://www.mdpi.com/2076-3425/15/7/675
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