Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak
ObjectivesTo investigate the epidemiological and clinical characteristics of children infected with the Omicron variant of SARS-CoV-2 during the early outbreak in Beijing, with particular attention to symptom profiles, clinical management, and persistent symptoms at 12 weeks post-infection.MethodsTh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1389572/full |
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| author | Qin Hui Jing Liu Hua Fan Xiaonan Hou Xuan Li Wei Li Qi Zhang |
| author_facet | Qin Hui Jing Liu Hua Fan Xiaonan Hou Xuan Li Wei Li Qi Zhang |
| author_sort | Qin Hui |
| collection | DOAJ |
| description | ObjectivesTo investigate the epidemiological and clinical characteristics of children infected with the Omicron variant of SARS-CoV-2 during the early outbreak in Beijing, with particular attention to symptom profiles, clinical management, and persistent symptoms at 12 weeks post-infection.MethodsThis prospective study enrolled children under 18 years of age with confirmed or suspected Omicron infection in Beijing between December 2022 and January 2023. Data were collected via an online questionnaire targeting both community-managed and outpatient children. A follow-up survey was conducted at 12 weeks post-infection to assess long-term symptoms.ResultsA total of 1,610 children aged 15 days to 18 years were included (median age: 3.00 years; 51.4% boys). Fever (96.4%) was the most common symptom, with a mean peak temperature of 39°C (range: 37.6–41°C). Other frequent symptoms included cough (59.1%), runny nose (43.7%), and fatigue (22.1%). The mean duration of fever was 2.05 ± 1.09 days, and the mean duration of all symptoms was 5.89 ± 4.35 days, with both showing significant differences across age groups (p < 0.001). By one week post-infection, symptoms had resolved in 34.2% of cases. At 12 weeks, 2.9% (43/1,471) of children still reported persistent symptoms. The most common were cough (1.4%), nasal congestion (1.1%), dry throat and exertional dyspnea (each 0.7%), and fatigue (0.6%).ConclusionsOmicron infection affected children across all age groups, with a higher prevalence in younger children. Fever and cough were the predominant acute symptoms, while a small subset reported mild persistent symptoms 12 weeks post-infection. |
| format | Article |
| id | doaj-art-e3708456739f4e6db1a142ead4e500b9 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-e3708456739f4e6db1a142ead4e500b92025-08-20T03:43:55ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-08-011310.3389/fped.2025.13895721389572Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreakQin HuiJing LiuHua FanXiaonan HouXuan LiWei LiQi ZhangObjectivesTo investigate the epidemiological and clinical characteristics of children infected with the Omicron variant of SARS-CoV-2 during the early outbreak in Beijing, with particular attention to symptom profiles, clinical management, and persistent symptoms at 12 weeks post-infection.MethodsThis prospective study enrolled children under 18 years of age with confirmed or suspected Omicron infection in Beijing between December 2022 and January 2023. Data were collected via an online questionnaire targeting both community-managed and outpatient children. A follow-up survey was conducted at 12 weeks post-infection to assess long-term symptoms.ResultsA total of 1,610 children aged 15 days to 18 years were included (median age: 3.00 years; 51.4% boys). Fever (96.4%) was the most common symptom, with a mean peak temperature of 39°C (range: 37.6–41°C). Other frequent symptoms included cough (59.1%), runny nose (43.7%), and fatigue (22.1%). The mean duration of fever was 2.05 ± 1.09 days, and the mean duration of all symptoms was 5.89 ± 4.35 days, with both showing significant differences across age groups (p < 0.001). By one week post-infection, symptoms had resolved in 34.2% of cases. At 12 weeks, 2.9% (43/1,471) of children still reported persistent symptoms. The most common were cough (1.4%), nasal congestion (1.1%), dry throat and exertional dyspnea (each 0.7%), and fatigue (0.6%).ConclusionsOmicron infection affected children across all age groups, with a higher prevalence in younger children. Fever and cough were the predominant acute symptoms, while a small subset reported mild persistent symptoms 12 weeks post-infection.https://www.frontiersin.org/articles/10.3389/fped.2025.1389572/fullchildrenomicronsymptomCOVID-19Beijing |
| spellingShingle | Qin Hui Jing Liu Hua Fan Xiaonan Hou Xuan Li Wei Li Qi Zhang Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak Frontiers in Pediatrics children omicron symptom COVID-19 Beijing |
| title | Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak |
| title_full | Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak |
| title_fullStr | Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak |
| title_full_unstemmed | Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak |
| title_short | Early symptoms and 12-week follow-up of pediatric omicron infections during the Beijing outbreak |
| title_sort | early symptoms and 12 week follow up of pediatric omicron infections during the beijing outbreak |
| topic | children omicron symptom COVID-19 Beijing |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1389572/full |
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