The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases
The role of microbiota in human health and disease is becoming increasingly clear as a result of modern microbiome studies in recent decades. The gastrointestinal tract is the major habitat for microbiota in the human body. This microbiota comprises several trillion microorganisms, which is equivale...
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2024-12-01
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| author | Jagriti Verma Md Tanveer Anwar Bodo Linz Steffen Backert Suneesh Kumar Pachathundikandi |
| author_facet | Jagriti Verma Md Tanveer Anwar Bodo Linz Steffen Backert Suneesh Kumar Pachathundikandi |
| author_sort | Jagriti Verma |
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| description | The role of microbiota in human health and disease is becoming increasingly clear as a result of modern microbiome studies in recent decades. The gastrointestinal tract is the major habitat for microbiota in the human body. This microbiota comprises several trillion microorganisms, which is equivalent to almost ten times the total number of cells of the human host. <i>Helicobacter pylori</i> is a known pathogen that colonizes the gastric mucosa of almost half of the world population. <i>H. pylori</i> is associated with several gastric diseases, including gastric cancer (GC) development. However, the impact of the gastric microbiota in the colonization, chronic infection, and pathogenesis is still not fully understood. Several studies have documented qualitative and quantitative changes in the microbiota’s composition in the presence or absence of this pathogen. Among the diverse microflora in the stomach, the Firmicutes represent the most notable. Bacteria such as <i>Prevotella</i> sp., <i>Clostridium</i> sp., <i>Lactobacillus</i> sp., and <i>Veillonella</i> sp. were frequently found in the healthy human stomach. In contrast, <i>H</i>.<i>pylori</i> is very dominant during chronic gastritis, increasing the proportion of Proteobacteria in the total microbiota to almost 80%, with decreasing relative proportions of Firmicutes. Likewise, <i>H. pylori</i> and <i>Streptococcus</i> are the most abundant bacteria during peptic ulcer disease. While the development of <i>H. pylori</i>-associated intestinal metaplasia is accompanied by an increase in Bacteroides, the stomachs of GC patients are dominated by Firmicutes such as <i>Lactobacillus</i> and <i>Veillonella</i>, constituting up to 40% of the total microbiota, and by Bacteroidetes such as <i>Prevotella</i>, whereas the numbers of <i>H. pylori</i> are decreasing. This review focuses on some of the consequences of changes in the gastric microbiota and the function of probiotics to modulate <i>H. pylori</i> infection and dysbiosis in general. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-e36f6d90890940039f8e0e7468e2fa402025-01-24T13:23:53ZengMDPI AGBiomedicines2227-90592024-12-011316110.3390/biomedicines13010061The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated DiseasesJagriti Verma0Md Tanveer Anwar1Bodo Linz2Steffen Backert3Suneesh Kumar Pachathundikandi4Department of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, IndiaDepartment of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, IndiaChair of Microbiology, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, GermanyChair of Microbiology, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, GermanyDepartment of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, IndiaThe role of microbiota in human health and disease is becoming increasingly clear as a result of modern microbiome studies in recent decades. The gastrointestinal tract is the major habitat for microbiota in the human body. This microbiota comprises several trillion microorganisms, which is equivalent to almost ten times the total number of cells of the human host. <i>Helicobacter pylori</i> is a known pathogen that colonizes the gastric mucosa of almost half of the world population. <i>H. pylori</i> is associated with several gastric diseases, including gastric cancer (GC) development. However, the impact of the gastric microbiota in the colonization, chronic infection, and pathogenesis is still not fully understood. Several studies have documented qualitative and quantitative changes in the microbiota’s composition in the presence or absence of this pathogen. Among the diverse microflora in the stomach, the Firmicutes represent the most notable. Bacteria such as <i>Prevotella</i> sp., <i>Clostridium</i> sp., <i>Lactobacillus</i> sp., and <i>Veillonella</i> sp. were frequently found in the healthy human stomach. In contrast, <i>H</i>.<i>pylori</i> is very dominant during chronic gastritis, increasing the proportion of Proteobacteria in the total microbiota to almost 80%, with decreasing relative proportions of Firmicutes. Likewise, <i>H. pylori</i> and <i>Streptococcus</i> are the most abundant bacteria during peptic ulcer disease. While the development of <i>H. pylori</i>-associated intestinal metaplasia is accompanied by an increase in Bacteroides, the stomachs of GC patients are dominated by Firmicutes such as <i>Lactobacillus</i> and <i>Veillonella</i>, constituting up to 40% of the total microbiota, and by Bacteroidetes such as <i>Prevotella</i>, whereas the numbers of <i>H. pylori</i> are decreasing. This review focuses on some of the consequences of changes in the gastric microbiota and the function of probiotics to modulate <i>H. pylori</i> infection and dysbiosis in general.https://www.mdpi.com/2227-9059/13/1/61<i>H. pylori</i>gastric microbiotaprobioticspeptic ulcer diseasegastric cancerMALT lymphoma |
| spellingShingle | Jagriti Verma Md Tanveer Anwar Bodo Linz Steffen Backert Suneesh Kumar Pachathundikandi The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases Biomedicines <i>H. pylori</i> gastric microbiota probiotics peptic ulcer disease gastric cancer MALT lymphoma |
| title | The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases |
| title_full | The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases |
| title_fullStr | The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases |
| title_full_unstemmed | The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases |
| title_short | The Influence of Gastric Microbiota and Probiotics in <i>Helicobacter pylori</i> Infection and Associated Diseases |
| title_sort | influence of gastric microbiota and probiotics in i helicobacter pylori i infection and associated diseases |
| topic | <i>H. pylori</i> gastric microbiota probiotics peptic ulcer disease gastric cancer MALT lymphoma |
| url | https://www.mdpi.com/2227-9059/13/1/61 |
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