Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging
Background. The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinom...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2017/9647010 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550385622974464 |
|---|---|
| author | Fukuko Shimizu Kenji Okami Koji Ebisumoto Daisuke Maki Akihiro Sakai Go Ogura Naoya Nakamura Masahiro Iida |
| author_facet | Fukuko Shimizu Kenji Okami Koji Ebisumoto Daisuke Maki Akihiro Sakai Go Ogura Naoya Nakamura Masahiro Iida |
| author_sort | Fukuko Shimizu |
| collection | DOAJ |
| description | Background. The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Methods and Results. We report the case of a 63-year-old male with bilateral tonsillar carcinoma detected using transoral endoscopic examination with narrow-band imaging (NBI). A biopsy of the bilateral tonsils revealed squamous cell carcinoma, which was demonstrated to be HPV-related using in situ hybridization and p16 immunohistochemistry. The patient was diagnosed as synchronous bilateral tonsillar carcinoma: T1 (2) N2b M0. He was treated with induction chemotherapy, bilateral radical tonsillectomy with neck dissection, and radiotherapy. Conclusion. To our knowledge, this is the first report of a synchronous bilateral tonsillar carcinoma detected using transoral NBI in the outpatient setting. Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion. |
| format | Article |
| id | doaj-art-e36a55c25abf45c18f51ea8080ce8d78 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-e36a55c25abf45c18f51ea8080ce8d782025-02-03T06:07:02ZengWileyCase Reports in Otolaryngology2090-67652090-67732017-01-01201710.1155/2017/96470109647010Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band ImagingFukuko Shimizu0Kenji Okami1Koji Ebisumoto2Daisuke Maki3Akihiro Sakai4Go Ogura5Naoya Nakamura6Masahiro Iida7Department of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, JapanDepartment of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, JapanDepartment of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, JapanDepartment of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, JapanDepartment of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, JapanDepartment of Pathology, Tokai University, Isehara, JapanDepartment of Pathology, Tokai University, Isehara, JapanDepartment of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, JapanBackground. The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Methods and Results. We report the case of a 63-year-old male with bilateral tonsillar carcinoma detected using transoral endoscopic examination with narrow-band imaging (NBI). A biopsy of the bilateral tonsils revealed squamous cell carcinoma, which was demonstrated to be HPV-related using in situ hybridization and p16 immunohistochemistry. The patient was diagnosed as synchronous bilateral tonsillar carcinoma: T1 (2) N2b M0. He was treated with induction chemotherapy, bilateral radical tonsillectomy with neck dissection, and radiotherapy. Conclusion. To our knowledge, this is the first report of a synchronous bilateral tonsillar carcinoma detected using transoral NBI in the outpatient setting. Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion.http://dx.doi.org/10.1155/2017/9647010 |
| spellingShingle | Fukuko Shimizu Kenji Okami Koji Ebisumoto Daisuke Maki Akihiro Sakai Go Ogura Naoya Nakamura Masahiro Iida Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging Case Reports in Otolaryngology |
| title | Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging |
| title_full | Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging |
| title_fullStr | Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging |
| title_full_unstemmed | Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging |
| title_short | Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging |
| title_sort | synchronous hpv related cancer of bilateral tonsils detected using transoral endoscopic examination with narrow band imaging |
| url | http://dx.doi.org/10.1155/2017/9647010 |
| work_keys_str_mv | AT fukukoshimizu synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT kenjiokami synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT kojiebisumoto synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT daisukemaki synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT akihirosakai synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT googura synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT naoyanakamura synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging AT masahiroiida synchronoushpvrelatedcancerofbilateraltonsilsdetectedusingtransoralendoscopicexaminationwithnarrowbandimaging |