Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes
Ni(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3), and 3-((2-mercaptoph...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2014/568741 |
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| author | Palakuri Kavitha K. Laxma Reddy |
| author_facet | Palakuri Kavitha K. Laxma Reddy |
| author_sort | Palakuri Kavitha |
| collection | DOAJ |
| description | Ni(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3), and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4). All the complexes were characterized in the light of elemental analysis, molar conductance, FTIR, UV-VIS, magnetic, thermal, powder XRD, and SEM studies. The conductance and spectroscopic data suggested that, the ligands act as neutral and monobasic tridentate ligands and form octahedral complexes with general formula [M(L1–4)2]·nH2O (M = Ni(II) and Zn(II)). Metal complexes exhibited pronounced activity against tested bacteria and fungi strains compared to the ligands. In addition metal complexes displayed good antioxidant and moderate nematicidal activities. The cytotoxicity of ligands and their metal complexes have been evaluated by MTT assay. The DNA cleavage activity of the metal complexes was performed using agarose gel electrophoresis in the presence and absence of oxidant H2O2. All metal complexes showed significant nuclease activity in the presence of H2O2. |
| format | Article |
| id | doaj-art-e36799274a9a42e393120feb31ceeacc |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-e36799274a9a42e393120feb31ceeacc2025-08-20T03:26:31ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2014-01-01201410.1155/2014/568741568741Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) ComplexesPalakuri Kavitha0K. Laxma Reddy1Department of Chemistry, National Institute of Technology, Warangal 506 004, IndiaDepartment of Chemistry, National Institute of Technology, Warangal 506 004, IndiaNi(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3), and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4). All the complexes were characterized in the light of elemental analysis, molar conductance, FTIR, UV-VIS, magnetic, thermal, powder XRD, and SEM studies. The conductance and spectroscopic data suggested that, the ligands act as neutral and monobasic tridentate ligands and form octahedral complexes with general formula [M(L1–4)2]·nH2O (M = Ni(II) and Zn(II)). Metal complexes exhibited pronounced activity against tested bacteria and fungi strains compared to the ligands. In addition metal complexes displayed good antioxidant and moderate nematicidal activities. The cytotoxicity of ligands and their metal complexes have been evaluated by MTT assay. The DNA cleavage activity of the metal complexes was performed using agarose gel electrophoresis in the presence and absence of oxidant H2O2. All metal complexes showed significant nuclease activity in the presence of H2O2.http://dx.doi.org/10.1155/2014/568741 |
| spellingShingle | Palakuri Kavitha K. Laxma Reddy Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes |
| title_full | Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes |
| title_fullStr | Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes |
| title_full_unstemmed | Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes |
| title_short | Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes |
| title_sort | synthesis structural characterization and biological activity studies of ni ii and zn ii complexes |
| url | http://dx.doi.org/10.1155/2014/568741 |
| work_keys_str_mv | AT palakurikavitha synthesisstructuralcharacterizationandbiologicalactivitystudiesofniiiandzniicomplexes AT klaxmareddy synthesisstructuralcharacterizationandbiologicalactivitystudiesofniiiandzniicomplexes |