Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report
Abstract Background Despite recent advances in systemic chemotherapy, the prognosis of patients with peritoneal metastases from gastric cancer still remains poor. Nonetheless, several efficacious intraperitoneal chemotherapy regimens have recently been developed for patients with peritoneal metastas...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Surgical Society
2020-05-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00849-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849395896564842496 |
|---|---|
| author | Kozo Miyatani Wataru Miyauchi Yusuke Kono Yuji Shishido Joji Watanabe Takehiko Hanaki Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Yoji Fukumoto Naruo Tokuyasu Shuichi Takano Teruhisa Sakamoto Soichiro Honjo Toshimichi Hasegawa Yoshiyuki Fujiwara |
| author_facet | Kozo Miyatani Wataru Miyauchi Yusuke Kono Yuji Shishido Joji Watanabe Takehiko Hanaki Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Yoji Fukumoto Naruo Tokuyasu Shuichi Takano Teruhisa Sakamoto Soichiro Honjo Toshimichi Hasegawa Yoshiyuki Fujiwara |
| author_sort | Kozo Miyatani |
| collection | DOAJ |
| description | Abstract Background Despite recent advances in systemic chemotherapy, the prognosis of patients with peritoneal metastases from gastric cancer still remains poor. Nonetheless, several efficacious intraperitoneal chemotherapy regimens have recently been developed for patients with peritoneal metastases. However, no study has investigated the effectiveness of intraperitoneal chemotherapy for metachronous peritoneal metastases from gastric cancer after curative surgery. Case presentation We herein report a case of a 65-year-old man who had metachronous peritoneal metastases from gastric cancer after curative total gastrectomy who had been successfully treated with intraperitoneal chemotherapy. One month after surgery, adjuvant chemotherapy with S-1 was initiated given a final pathological stage of IIIB (pT4aN2M0). However, during adjuvant chemotherapy 12 months after surgery, tumor marker levels, which had been within normal range before surgery, increased with abdominal contrast-enhanced computed tomography (CT) revealing pelvic ascites. Thereafter, staging laparoscopy was performed, and the patient was diagnosed with peritoneal recurrence of gastric cancer. Following staging laparoscopy, an intraperitoneal access port was subcutaneously implanted for subsequent intraperitoneal chemotherapy. Combined chemotherapy with intraperitoneal and intravenous administration of paclitaxel and oral S-1 was then provided. After one course of combined chemotherapy, peritoneal lavage cytology was negative for malignancy. CT showed gradually decreasing ascites, whereas tumor marker levels returned to normal. The patient continued chemotherapy without major side effects and remained progression-free for 33 months with 36 chemotherapy cycles. Conclusions A combination regimen including intraperitoneal chemotherapy could be a promising option for patients with peritoneal recurrence after gastric cancer surgery. |
| format | Article |
| id | doaj-art-e361df68f3224086bca4b9fbc8f7d60b |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-05-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-e361df68f3224086bca4b9fbc8f7d60b2025-08-20T03:39:28ZengJapan Surgical SocietySurgical Case Reports2198-77932020-05-01611510.1186/s40792-020-00849-2Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case reportKozo Miyatani0Wataru Miyauchi1Yusuke Kono2Yuji Shishido3Joji Watanabe4Takehiko Hanaki5Kyoichi Kihara6Tomoyuki Matsunaga7Manabu Yamamoto8Yoji Fukumoto9Naruo Tokuyasu10Shuichi Takano11Teruhisa Sakamoto12Soichiro Honjo13Toshimichi Hasegawa14Yoshiyuki Fujiwara15Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineDivision of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of MedicineAbstract Background Despite recent advances in systemic chemotherapy, the prognosis of patients with peritoneal metastases from gastric cancer still remains poor. Nonetheless, several efficacious intraperitoneal chemotherapy regimens have recently been developed for patients with peritoneal metastases. However, no study has investigated the effectiveness of intraperitoneal chemotherapy for metachronous peritoneal metastases from gastric cancer after curative surgery. Case presentation We herein report a case of a 65-year-old man who had metachronous peritoneal metastases from gastric cancer after curative total gastrectomy who had been successfully treated with intraperitoneal chemotherapy. One month after surgery, adjuvant chemotherapy with S-1 was initiated given a final pathological stage of IIIB (pT4aN2M0). However, during adjuvant chemotherapy 12 months after surgery, tumor marker levels, which had been within normal range before surgery, increased with abdominal contrast-enhanced computed tomography (CT) revealing pelvic ascites. Thereafter, staging laparoscopy was performed, and the patient was diagnosed with peritoneal recurrence of gastric cancer. Following staging laparoscopy, an intraperitoneal access port was subcutaneously implanted for subsequent intraperitoneal chemotherapy. Combined chemotherapy with intraperitoneal and intravenous administration of paclitaxel and oral S-1 was then provided. After one course of combined chemotherapy, peritoneal lavage cytology was negative for malignancy. CT showed gradually decreasing ascites, whereas tumor marker levels returned to normal. The patient continued chemotherapy without major side effects and remained progression-free for 33 months with 36 chemotherapy cycles. Conclusions A combination regimen including intraperitoneal chemotherapy could be a promising option for patients with peritoneal recurrence after gastric cancer surgery.http://link.springer.com/article/10.1186/s40792-020-00849-2Gastric cancerPeritoneal metastasisPeritoneal recurrenceMetachronous peritoneal metastasisIntraperitoneal chemotherapyPaclitaxel |
| spellingShingle | Kozo Miyatani Wataru Miyauchi Yusuke Kono Yuji Shishido Joji Watanabe Takehiko Hanaki Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Yoji Fukumoto Naruo Tokuyasu Shuichi Takano Teruhisa Sakamoto Soichiro Honjo Toshimichi Hasegawa Yoshiyuki Fujiwara Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report Surgical Case Reports Gastric cancer Peritoneal metastasis Peritoneal recurrence Metachronous peritoneal metastasis Intraperitoneal chemotherapy Paclitaxel |
| title | Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report |
| title_full | Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report |
| title_fullStr | Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report |
| title_full_unstemmed | Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report |
| title_short | Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report |
| title_sort | successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with s 1 chemotherapy a case report |
| topic | Gastric cancer Peritoneal metastasis Peritoneal recurrence Metachronous peritoneal metastasis Intraperitoneal chemotherapy Paclitaxel |
| url | http://link.springer.com/article/10.1186/s40792-020-00849-2 |
| work_keys_str_mv | AT kozomiyatani successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT watarumiyauchi successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT yusukekono successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT yujishishido successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT jojiwatanabe successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT takehikohanaki successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT kyoichikihara successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT tomoyukimatsunaga successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT manabuyamamoto successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT yojifukumoto successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT naruotokuyasu successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT shuichitakano successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT teruhisasakamoto successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT soichirohonjo successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT toshimichihasegawa successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport AT yoshiyukifujiwara successfultreatmentofperitonealrecurrenceaftergastriccancersurgerywithintravenousandintraperitonealpaclitaxelcombinedwiths1chemotherapyacasereport |