Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma

Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma

IntroductionIntra-tumoral heterogeneity is a prominent characteristic of hepatocellular carcinoma (HCC). However, it remains unexplored whether intra-tumoral transcriptomic differences can capture crucial information regarding HCC evolution and be utilized to derive a predictive signature for patien...

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Bibliographic Details
Main Authors: Shangyi Luo, Li Liu, Yang Sun, Jian Shi, Yajing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Bioinformatics
Subjects:
hepatocellular carcinoma
multi-region sequencing
expression dynamics
tumor evolution
prognostication
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1669236/full
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