Advances in Research Related to MicroRNA for Diabetic Retinopathy
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progres...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2024/8520489 |
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| author | Yahan Luo Chunxia Li |
| author_facet | Yahan Luo Chunxia Li |
| author_sort | Yahan Luo |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia, blood pressure, and lipid control, which includes laser photocoagulation, glucocorticoids, vitrectomy, and antivascular endothelial growth factor (anti-VEGF) medications. Despite the clinical efficacy of the aforementioned therapies, none of them can entirely shorten the clinical course of DR or reverse retinopathy. MicroRNAs (miRNAs) are vital regulators of gene expression and participate in cell growth, differentiation, development, and apoptosis. MicroRNAs have been shown to play a significant role in DR, particularly in the molecular mechanisms of inflammation, oxidative stress, and neurodegeneration. The aim of this review is to systematically summarize the signaling pathways and molecular mechanisms of miRNAs involved in the occurrence and development of DR, mainly from the pathogenesis of oxidative stress, inflammation, and neovascularization. Meanwhile, this article also discusses the research progress and application of miRNA-specific therapies for DR. |
| format | Article |
| id | doaj-art-e3588b37f14e476b9d167bf3d89c38c6 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e3588b37f14e476b9d167bf3d89c38c62025-02-03T07:23:41ZengWileyJournal of Diabetes Research2314-67532024-01-01202410.1155/2024/8520489Advances in Research Related to MicroRNA for Diabetic RetinopathyYahan Luo0Chunxia Li1Shanghai TCM-Integrated HospitalShanghai TCM-Integrated HospitalDiabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia, blood pressure, and lipid control, which includes laser photocoagulation, glucocorticoids, vitrectomy, and antivascular endothelial growth factor (anti-VEGF) medications. Despite the clinical efficacy of the aforementioned therapies, none of them can entirely shorten the clinical course of DR or reverse retinopathy. MicroRNAs (miRNAs) are vital regulators of gene expression and participate in cell growth, differentiation, development, and apoptosis. MicroRNAs have been shown to play a significant role in DR, particularly in the molecular mechanisms of inflammation, oxidative stress, and neurodegeneration. The aim of this review is to systematically summarize the signaling pathways and molecular mechanisms of miRNAs involved in the occurrence and development of DR, mainly from the pathogenesis of oxidative stress, inflammation, and neovascularization. Meanwhile, this article also discusses the research progress and application of miRNA-specific therapies for DR.http://dx.doi.org/10.1155/2024/8520489 |
| spellingShingle | Yahan Luo Chunxia Li Advances in Research Related to MicroRNA for Diabetic Retinopathy Journal of Diabetes Research |
| title | Advances in Research Related to MicroRNA for Diabetic Retinopathy |
| title_full | Advances in Research Related to MicroRNA for Diabetic Retinopathy |
| title_fullStr | Advances in Research Related to MicroRNA for Diabetic Retinopathy |
| title_full_unstemmed | Advances in Research Related to MicroRNA for Diabetic Retinopathy |
| title_short | Advances in Research Related to MicroRNA for Diabetic Retinopathy |
| title_sort | advances in research related to microrna for diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2024/8520489 |
| work_keys_str_mv | AT yahanluo advancesinresearchrelatedtomicrornafordiabeticretinopathy AT chunxiali advancesinresearchrelatedtomicrornafordiabeticretinopathy |