Cutting-Edge Approaches in the Co-Amorphization Process
<b>Background:</b> Recently, the co-amorphization method has been widely used to refine the bioavailability characteristics of poorly soluble drugs in addition to overcoming the drawbacks of other traditional amorphization techniques. <b>Objectives:</b> The main aim of this s...
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MDPI AG
2025-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/7/850 |
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| author | Azza A. K. Mahmoud Géza Regdon Katalin Kristó |
| author_facet | Azza A. K. Mahmoud Géza Regdon Katalin Kristó |
| author_sort | Azza A. K. Mahmoud |
| collection | DOAJ |
| description | <b>Background:</b> Recently, the co-amorphization method has been widely used to refine the bioavailability characteristics of poorly soluble drugs in addition to overcoming the drawbacks of other traditional amorphization techniques. <b>Objectives:</b> The main aim of this systematic review is to present an extensive outline of different co-former classes, co-former selection, and evaluation of produced co-amorphous systems. Methods: The systematic research was carried out based on three different databases, including PubMed, Scopus, and Web of Science time using co-amorphous, co-former, and drug as keywords. The selected papers were written in the English language and published between 2016 and 2024, and they focused on the co-amorphous systems, while articles discussing other amorphization techniques and crystallization processes were excluded. <b>Results:</b> 127 peer-reviewed articles were selected and summarized. <b>Conclusions:</b> This paper revealed that amino acid is the most commonly used co-former, specifically arginine with acidic drugs and tryptophan with acidic and basic drugs, and it reported other co-formers that were used and different co-amorphous systems with their dissolution behaviour and stabilities, and different computational tools that were applied in the selection of co-former and process result evaluation. |
| format | Article |
| id | doaj-art-e355a628fddd43a9ade2575d94d89abe |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-e355a628fddd43a9ade2575d94d89abe2025-08-20T02:47:05ZengMDPI AGPharmaceutics1999-49232025-06-0117785010.3390/pharmaceutics17070850Cutting-Edge Approaches in the Co-Amorphization ProcessAzza A. K. Mahmoud0Géza Regdon1Katalin Kristó2Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary<b>Background:</b> Recently, the co-amorphization method has been widely used to refine the bioavailability characteristics of poorly soluble drugs in addition to overcoming the drawbacks of other traditional amorphization techniques. <b>Objectives:</b> The main aim of this systematic review is to present an extensive outline of different co-former classes, co-former selection, and evaluation of produced co-amorphous systems. Methods: The systematic research was carried out based on three different databases, including PubMed, Scopus, and Web of Science time using co-amorphous, co-former, and drug as keywords. The selected papers were written in the English language and published between 2016 and 2024, and they focused on the co-amorphous systems, while articles discussing other amorphization techniques and crystallization processes were excluded. <b>Results:</b> 127 peer-reviewed articles were selected and summarized. <b>Conclusions:</b> This paper revealed that amino acid is the most commonly used co-former, specifically arginine with acidic drugs and tryptophan with acidic and basic drugs, and it reported other co-formers that were used and different co-amorphous systems with their dissolution behaviour and stabilities, and different computational tools that were applied in the selection of co-former and process result evaluation.https://www.mdpi.com/1999-4923/17/7/850co-formeramino acidsdrug–drug co-amorphizationdensity functional theoryprincipal component analysis |
| spellingShingle | Azza A. K. Mahmoud Géza Regdon Katalin Kristó Cutting-Edge Approaches in the Co-Amorphization Process Pharmaceutics co-former amino acids drug–drug co-amorphization density functional theory principal component analysis |
| title | Cutting-Edge Approaches in the Co-Amorphization Process |
| title_full | Cutting-Edge Approaches in the Co-Amorphization Process |
| title_fullStr | Cutting-Edge Approaches in the Co-Amorphization Process |
| title_full_unstemmed | Cutting-Edge Approaches in the Co-Amorphization Process |
| title_short | Cutting-Edge Approaches in the Co-Amorphization Process |
| title_sort | cutting edge approaches in the co amorphization process |
| topic | co-former amino acids drug–drug co-amorphization density functional theory principal component analysis |
| url | https://www.mdpi.com/1999-4923/17/7/850 |
| work_keys_str_mv | AT azzaakmahmoud cuttingedgeapproachesinthecoamorphizationprocess AT gezaregdon cuttingedgeapproachesinthecoamorphizationprocess AT katalinkristo cuttingedgeapproachesinthecoamorphizationprocess |