Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics
Abstract Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03141-3 |
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| author | Anmei Chen Ying Gong Shaoquan Wu Ye Du Zhijun Liu Yuhong Jiang Jiahong Li Yang-Bao Miao |
| author_facet | Anmei Chen Ying Gong Shaoquan Wu Ye Du Zhijun Liu Yuhong Jiang Jiahong Li Yang-Bao Miao |
| author_sort | Anmei Chen |
| collection | DOAJ |
| description | Abstract Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and enhancing the stability and bioavailability of these probiotics. This review explores the innovative application of nanoparticle-armored engineered probiotics for precise disease treatment, specifically addressing the physiological barriers associated with oral administration. A comprehensive evaluation of various nano-armor probiotics and encapsulation methods is provided, carefully analyzing their respective merits and limitations, alongside strategies to enhance probiotic survival and achieve targeted delivery and colonization within the gastrointestinal tract. Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of ‘probiotic intestinal colonization with nano armor’ for brain-targeted therapies. Ultimately, this review aspires to guide the advancement of nano-armored probiotic therapies, driving progress in precision medicine and paving the way for groundbreaking treatment modalities. Graphical abstract |
| format | Article |
| id | doaj-art-e349b35a214c4c2da630a08b12eaa3dc |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-e349b35a214c4c2da630a08b12eaa3dc2025-02-02T12:41:05ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123115010.1186/s12951-025-03141-3Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probioticsAnmei Chen0Ying Gong1Shaoquan Wu2Ye Du3Zhijun Liu4Yuhong Jiang5Jiahong Li6Yang-Bao Miao7School of Life Science and Engineering, Southwest Jiaotong UniversitySchool of Life Science and Engineering, Southwest Jiaotong UniversitySchool of Life Science and Engineering, Southwest Jiaotong UniversitySchool of Life Science and Engineering, Southwest Jiaotong UniversityUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen UniversitySchool of Life Science and Engineering, Southwest Jiaotong UniversitySchool of Life Science and Engineering, Southwest Jiaotong UniversityDepartment of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine of University of Electronic Science and Technology of ChinaAbstract Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and enhancing the stability and bioavailability of these probiotics. This review explores the innovative application of nanoparticle-armored engineered probiotics for precise disease treatment, specifically addressing the physiological barriers associated with oral administration. A comprehensive evaluation of various nano-armor probiotics and encapsulation methods is provided, carefully analyzing their respective merits and limitations, alongside strategies to enhance probiotic survival and achieve targeted delivery and colonization within the gastrointestinal tract. Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of ‘probiotic intestinal colonization with nano armor’ for brain-targeted therapies. Ultimately, this review aspires to guide the advancement of nano-armored probiotic therapies, driving progress in precision medicine and paving the way for groundbreaking treatment modalities. Graphical abstracthttps://doi.org/10.1186/s12951-025-03141-3ProbioticsNanoparticlesOral administrationGut to brainPrecision therapy |
| spellingShingle | Anmei Chen Ying Gong Shaoquan Wu Ye Du Zhijun Liu Yuhong Jiang Jiahong Li Yang-Bao Miao Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics Journal of Nanobiotechnology Probiotics Nanoparticles Oral administration Gut to brain Precision therapy |
| title | Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics |
| title_full | Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics |
| title_fullStr | Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics |
| title_full_unstemmed | Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics |
| title_short | Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics |
| title_sort | navigating a challenging path precision disease treatment with tailored oral nano armor probiotics |
| topic | Probiotics Nanoparticles Oral administration Gut to brain Precision therapy |
| url | https://doi.org/10.1186/s12951-025-03141-3 |
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