Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL
Type B lactic acidosis is a rare metabolic complication sometimes associated with hematologic malignancies. When present, this type of lactic acidosis is most commonly seen in patients with high-grade lymphomas or leukemias and is usually indicative of a dismal prognosis. We report a case of a 27-ye...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2018/9093623 |
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| _version_ | 1832558624750174208 |
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| author | Marco Mejia Ariel Perez Harold Watson Daniel Sanchez Jorge Parellada Mario Madruga S. J. Carlan |
| author_facet | Marco Mejia Ariel Perez Harold Watson Daniel Sanchez Jorge Parellada Mario Madruga S. J. Carlan |
| author_sort | Marco Mejia |
| collection | DOAJ |
| description | Type B lactic acidosis is a rare metabolic complication sometimes associated with hematologic malignancies. When present, this type of lactic acidosis is most commonly seen in patients with high-grade lymphomas or leukemias and is usually indicative of a dismal prognosis. We report a case of a 27-year man with acquired immunodeficiency syndrome (AIDS) that presented with bilateral lower extremity swelling, an abdominal mass, and weight loss. His lab values showed elevated anion gap with lactic acidosis and computed tomography (CT) of the abdomen showed a large soft-tissue mass arising from the left hepatic lobe. Biopsy of the abdominal mass demonstrated a high-grade diffuse large B-cell lymphoma. The patient’s lactic acidosis resolved after starting chemotherapy, and a complete response was evident on PET-CT after a third cycle of rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (EPOC-RR). Care-givers should be aware of the implications of lactic acidosis associated with malignancy and the need for prompt diagnosis and treatment. |
| format | Article |
| id | doaj-art-e3453f734e204a4faa3b23426b196889 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-e3453f734e204a4faa3b23426b1968892025-02-03T01:31:56ZengWileyCase Reports in Immunology2090-66092090-66172018-01-01201810.1155/2018/90936239093623Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHLMarco Mejia0Ariel Perez1Harold Watson2Daniel Sanchez3Jorge Parellada4Mario Madruga5S. J. Carlan6University of Central Florida College of Medicine, Orlando Regional Healthcare, Orlando, FL 32827, USADepartment of Medicine, Orlando Regional Healthcare, Orlando, FL, USADepartment of Medicine, Orlando Regional Healthcare, Orlando, FL, USADepartment of Pathology, Orlando Regional Healthcare, Orlando, FL, USADepartment of Medicine, Orlando Regional Healthcare, Orlando, FL, USAUniversity of Central Florida College of Medicine, Orlando Regional Healthcare, Orlando, FL 32827, USADivision of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL, USAType B lactic acidosis is a rare metabolic complication sometimes associated with hematologic malignancies. When present, this type of lactic acidosis is most commonly seen in patients with high-grade lymphomas or leukemias and is usually indicative of a dismal prognosis. We report a case of a 27-year man with acquired immunodeficiency syndrome (AIDS) that presented with bilateral lower extremity swelling, an abdominal mass, and weight loss. His lab values showed elevated anion gap with lactic acidosis and computed tomography (CT) of the abdomen showed a large soft-tissue mass arising from the left hepatic lobe. Biopsy of the abdominal mass demonstrated a high-grade diffuse large B-cell lymphoma. The patient’s lactic acidosis resolved after starting chemotherapy, and a complete response was evident on PET-CT after a third cycle of rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (EPOC-RR). Care-givers should be aware of the implications of lactic acidosis associated with malignancy and the need for prompt diagnosis and treatment.http://dx.doi.org/10.1155/2018/9093623 |
| spellingShingle | Marco Mejia Ariel Perez Harold Watson Daniel Sanchez Jorge Parellada Mario Madruga S. J. Carlan Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL Case Reports in Immunology |
| title | Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL |
| title_full | Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL |
| title_fullStr | Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL |
| title_full_unstemmed | Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL |
| title_short | Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL |
| title_sort | successful treatment of severe type b lactic acidosis in a patient with hiv aids associated high grade nhl |
| url | http://dx.doi.org/10.1155/2018/9093623 |
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