Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review
ObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson’s disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in P...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526095/full |
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| author | Hongxia Ma Ziyuan Wang Miao Yu Yibo Zhai Junqiang Yan Junqiang Yan |
| author_facet | Hongxia Ma Ziyuan Wang Miao Yu Yibo Zhai Junqiang Yan Junqiang Yan |
| author_sort | Hongxia Ma |
| collection | DOAJ |
| description | ObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson’s disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject.MethodsPubMed, Cochrane Library, and MEDLINE databases were searched until 3rd February 2024.ResultsWe included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients’ peripheral blood.ConclusionStudies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted. |
| format | Article |
| id | doaj-art-e33e4742e8e2438a92cda6cf245e653b |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e33e4742e8e2438a92cda6cf245e653b2025-08-20T02:10:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15260951526095Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic reviewHongxia Ma0Ziyuan Wang1Miao Yu2Yibo Zhai3Junqiang Yan4Junqiang Yan5Department of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaDepartment of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaDepartment of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaDepartment of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaDepartment of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaKey laboratory of Neuromolecular Biology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson’s disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject.MethodsPubMed, Cochrane Library, and MEDLINE databases were searched until 3rd February 2024.ResultsWe included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients’ peripheral blood.ConclusionStudies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526095/fullB lymphocyteB lymphocyte subsetsParkinson’s diseasePathogenesisImmunityInflammation |
| spellingShingle | Hongxia Ma Ziyuan Wang Miao Yu Yibo Zhai Junqiang Yan Junqiang Yan Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review Frontiers in Immunology B lymphocyte B lymphocyte subsets Parkinson’s disease Pathogenesis Immunity Inflammation |
| title | Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review |
| title_full | Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review |
| title_fullStr | Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review |
| title_full_unstemmed | Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review |
| title_short | Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review |
| title_sort | aberrations in peripheral b lymphocytes and b lymphocyte subsets levels in parkinson disease a systematic review |
| topic | B lymphocyte B lymphocyte subsets Parkinson’s disease Pathogenesis Immunity Inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526095/full |
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