Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis
Circulating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5202898 |
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| author | Zhenzhen Su Jie Chen Junlong Zhang Yunfei An Yun Liao Xiaojuan Wu Chuanmin Tao Lanlan Wang Bei Cai |
| author_facet | Zhenzhen Su Jie Chen Junlong Zhang Yunfei An Yun Liao Xiaojuan Wu Chuanmin Tao Lanlan Wang Bei Cai |
| author_sort | Zhenzhen Su |
| collection | DOAJ |
| description | Circulating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (IL)-17 may be helpful in HBV spontaneous clearance [odds ratio OR=1.468, 95%confidence interval CI=1.080–1.995, P=0.014] and protective against HBV-related hepatoma development (OR=0.933, 95%CI=0.910–0.957, P<0.001). IL-1β negatively affected HBV clearance (OR=0.052, 95%CI=0.005–0.534, P=0.013). In patients with chronic hepatitis B, interferon-γ-inducible protein-10 (IP-10) levels significantly increased in the group of abnormal liver function (P=0.006). Furthermore, positive correlations of IP-10 with alanine aminotransferase and aspartate aminotransferase levels were observed (rs=0.546 and 0.644, respectively; P<0.001). In conclusion, inflammatory cytokines and chemokines may be a “double-edged sword” for HBV clearance and progression. Further exploration of the roles of IL-17, IL-1β, and IP-10 in chronic HBV infection is needed. |
| format | Article |
| id | doaj-art-e32e90d539c247bbbf801768e59a2fc6 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e32e90d539c247bbbf801768e59a2fc62025-02-03T06:11:55ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5202898Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection PrognosisZhenzhen Su0Jie Chen1Junlong Zhang2Yunfei An3Yun Liao4Xiaojuan Wu5Chuanmin Tao6Lanlan Wang7Bei Cai8Department of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineDepartment of Laboratory Medicine/Research Centre of Clinical Laboratory MedicineCirculating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (IL)-17 may be helpful in HBV spontaneous clearance [odds ratio OR=1.468, 95%confidence interval CI=1.080–1.995, P=0.014] and protective against HBV-related hepatoma development (OR=0.933, 95%CI=0.910–0.957, P<0.001). IL-1β negatively affected HBV clearance (OR=0.052, 95%CI=0.005–0.534, P=0.013). In patients with chronic hepatitis B, interferon-γ-inducible protein-10 (IP-10) levels significantly increased in the group of abnormal liver function (P=0.006). Furthermore, positive correlations of IP-10 with alanine aminotransferase and aspartate aminotransferase levels were observed (rs=0.546 and 0.644, respectively; P<0.001). In conclusion, inflammatory cytokines and chemokines may be a “double-edged sword” for HBV clearance and progression. Further exploration of the roles of IL-17, IL-1β, and IP-10 in chronic HBV infection is needed.http://dx.doi.org/10.1155/2022/5202898 |
| spellingShingle | Zhenzhen Su Jie Chen Junlong Zhang Yunfei An Yun Liao Xiaojuan Wu Chuanmin Tao Lanlan Wang Bei Cai Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis Journal of Immunology Research |
| title | Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis |
| title_full | Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis |
| title_fullStr | Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis |
| title_full_unstemmed | Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis |
| title_short | Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis |
| title_sort | circulating il 1β il 17 and ip 10 as potential predictors of hepatitis b virus infection prognosis |
| url | http://dx.doi.org/10.1155/2022/5202898 |
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