Impact of Simulated Vascular Aging and Heart Rate on Myocardial Efficiency: A Tale of Two Paradigms from In Silico Modelling

Impact of Simulated Vascular Aging and Heart Rate on Myocardial Efficiency: A Tale of Two Paradigms from In Silico Modelling

Introduction: Vascular aging is associated with a loss of aortic compliance (C<sub>A</sub>), which results in increased left ventricular pressure–volume area (PVA), stroke work (SW) and myocardial oxygen consumption (MVO<sub>2</sub>). Myocardial efficiency (MyoEff) is derived...

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Bibliographic Details
Main Authors: Lawrence J. Mulligan, Julian Thrash, Ludmil Mitrev, Daniel Ewert, Jeffrey C. Hill
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
aortic compliance
pressure–volume area
myocardial oxygen consumption
myocardial efficiency
mechanical efficiency
computational modeling
Online Access:https://www.mdpi.com/2308-3425/12/5/163
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