Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations
ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Katiane R. Servelhere Ingrid Faber Alberto Martinez Renato Nickel Adriana Moro Francisco M. B. Germiniani Mariana Moscovich Tatiane R. Blume Renato P. Munhoz Hélio A. G. Teive Marcondes C. França Jr |
| author_facet | Katiane R. Servelhere Ingrid Faber Alberto Martinez Renato Nickel Adriana Moro Francisco M. B. Germiniani Mariana Moscovich Tatiane R. Blume Renato P. Munhoz Hélio A. G. Teive Marcondes C. França Jr |
| author_sort | Katiane R. Servelhere |
| collection | DOAJ |
| description | ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results Mean age was 41.7 ± 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment. |
| format | Article |
| id | doaj-art-e329a7dbe1444005b8578eef3600a00d |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e329a7dbe1444005b8578eef3600a00d2025-08-20T02:04:15ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-422776318318810.1590/0004-282x20180013S0004-282X2018000300183Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestationsKatiane R. ServelhereIngrid FaberAlberto MartinezRenato NickelAdriana MoroFrancisco M. B. GerminianiMariana MoscovichTatiane R. BlumeRenato P. MunhozHélio A. G. TeiveMarcondes C. França JrABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results Mean age was 41.7 ± 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300183&lng=en&tlng=entoxinas botulínicasparaparesia espástica hereditáriaespasticidade muscular |
| spellingShingle | Katiane R. Servelhere Ingrid Faber Alberto Martinez Renato Nickel Adriana Moro Francisco M. B. Germiniani Mariana Moscovich Tatiane R. Blume Renato P. Munhoz Hélio A. G. Teive Marcondes C. França Jr Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations Arquivos de Neuro-Psiquiatria toxinas botulínicas paraparesia espástica hereditária espasticidade muscular |
| title | Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
| title_full | Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
| title_fullStr | Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
| title_full_unstemmed | Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
| title_short | Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
| title_sort | botulinum toxin for hereditary spastic paraplegia effects on motor and non motor manifestations |
| topic | toxinas botulínicas paraparesia espástica hereditária espasticidade muscular |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300183&lng=en&tlng=en |
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