Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study
ABSTRACT Background and Aims Vasovagal syncope (VVS) is a primary reason for fainting in children, affected by numerous genetic and environmental factors. We designed this study to investigate the impact of SLC6A2 gene polymorphisms and gene‐environment interactions on the etiology of VVS in childre...
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Wiley
2025-03-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70585 |
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| author | Minmin Wang Meng Li Haizhao Zhao Xiaoyue Liu Qingyu Kong Cuifen Zhao Baomin Li |
| author_facet | Minmin Wang Meng Li Haizhao Zhao Xiaoyue Liu Qingyu Kong Cuifen Zhao Baomin Li |
| author_sort | Minmin Wang |
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| description | ABSTRACT Background and Aims Vasovagal syncope (VVS) is a primary reason for fainting in children, affected by numerous genetic and environmental factors. We designed this study to investigate the impact of SLC6A2 gene polymorphisms and gene‐environment interactions on the etiology of VVS in children. Methods This study was conducted with 142 children, comprising 71 VVS patients and 71 healthy controls. Five single nucleotide polymorphisms (SNPs) in the SLC6A2 gene (rs2242446, rs168924, rs2397771, rs5564, and rs5569) were genotyped using TaqMan assays. Clinical and hematological data were analyzed alongside genetic information. Results The rs2242446 TT genotype was significantly associated with VVS (CC + CT/TT, 31/40 vs. 45/26, χ2 = 5.55, p = 0.02), and the AA genotype of rs5564 was similarly correlated with increased VVS risk (GG + AG/AA, 39/32 vs. 27/44, χ2 = 4.08, p = 0.04). No significant associations were identified for rs168924, rs2397771, or rs5569. Additional risk factors include family history, elevated hemoglobin (HB) concentrations, increased mean corpuscular volume (MCV), and low vitamin D levels. Multivariate analysis showed that only rs2242446 remained significantly associated with VVS (CC + CT/TT; OR, 2.54; 95% CI; 1.12–5.75; p = 0.03). Vitamin D deficiency, family history, and certain hematological markers were also notable risk factors. Conclusion Polymorphisms in the SLC6A2 gene, particularly rs2242446, may increase the risk of VVS in children. Further research is needed to validate these findings and explore therapeutic interventions targeting the norepinephrine system. |
| format | Article |
| id | doaj-art-e328c3b11ebf4e78a2efc9d55310cd32 |
| institution | DOAJ |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
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| series | Health Science Reports |
| spelling | doaj-art-e328c3b11ebf4e78a2efc9d55310cd322025-08-20T02:54:29ZengWileyHealth Science Reports2398-88352025-03-0183n/an/a10.1002/hsr2.70585Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control StudyMinmin Wang0Meng Li1Haizhao Zhao2Xiaoyue Liu3Qingyu Kong4Cuifen Zhao5Baomin Li6Department of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaDepartment of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaDepartment of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaDepartment of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaDepartment of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaDepartment of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaDepartment of Pediatrics Qilu Hospital of Shandong University Jinan Shandong ChinaABSTRACT Background and Aims Vasovagal syncope (VVS) is a primary reason for fainting in children, affected by numerous genetic and environmental factors. We designed this study to investigate the impact of SLC6A2 gene polymorphisms and gene‐environment interactions on the etiology of VVS in children. Methods This study was conducted with 142 children, comprising 71 VVS patients and 71 healthy controls. Five single nucleotide polymorphisms (SNPs) in the SLC6A2 gene (rs2242446, rs168924, rs2397771, rs5564, and rs5569) were genotyped using TaqMan assays. Clinical and hematological data were analyzed alongside genetic information. Results The rs2242446 TT genotype was significantly associated with VVS (CC + CT/TT, 31/40 vs. 45/26, χ2 = 5.55, p = 0.02), and the AA genotype of rs5564 was similarly correlated with increased VVS risk (GG + AG/AA, 39/32 vs. 27/44, χ2 = 4.08, p = 0.04). No significant associations were identified for rs168924, rs2397771, or rs5569. Additional risk factors include family history, elevated hemoglobin (HB) concentrations, increased mean corpuscular volume (MCV), and low vitamin D levels. Multivariate analysis showed that only rs2242446 remained significantly associated with VVS (CC + CT/TT; OR, 2.54; 95% CI; 1.12–5.75; p = 0.03). Vitamin D deficiency, family history, and certain hematological markers were also notable risk factors. Conclusion Polymorphisms in the SLC6A2 gene, particularly rs2242446, may increase the risk of VVS in children. Further research is needed to validate these findings and explore therapeutic interventions targeting the norepinephrine system.https://doi.org/10.1002/hsr2.70585childrenetiologySLC6A2vasovagal syncope |
| spellingShingle | Minmin Wang Meng Li Haizhao Zhao Xiaoyue Liu Qingyu Kong Cuifen Zhao Baomin Li Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study Health Science Reports children etiology SLC6A2 vasovagal syncope |
| title | Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study |
| title_full | Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study |
| title_fullStr | Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study |
| title_full_unstemmed | Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study |
| title_short | Roles of Single Nucleotide Polymorphisms in the SLC6A2 Gene in the Risk of Vasovagal Syncope Among Children in Eastern China: A Case‐Control Study |
| title_sort | roles of single nucleotide polymorphisms in the slc6a2 gene in the risk of vasovagal syncope among children in eastern china a case control study |
| topic | children etiology SLC6A2 vasovagal syncope |
| url | https://doi.org/10.1002/hsr2.70585 |
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