A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis
The esophagus and stomach can be primary sites for Hodgkin lymphoma (HL). The pathognomonic feature of HL is the Reed-Sternberg cell. Because these cells can be rare in HL tumours, biopsies obtained via endoscopy are usually inadequate for establishing a definitive diagnosis. A case of a gastroesoph...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2007/362360 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564019015188480 |
|---|---|
| author | Garnet Horne Shaun AC Medlicott Adnan Mansoor Johan Lategan Raymond Lai P Beck |
| author_facet | Garnet Horne Shaun AC Medlicott Adnan Mansoor Johan Lategan Raymond Lai P Beck |
| author_sort | Garnet Horne |
| collection | DOAJ |
| description | The esophagus and stomach can be primary sites for Hodgkin lymphoma (HL). The pathognomonic feature of HL is the Reed-Sternberg cell. Because these cells can be rare in HL tumours, biopsies obtained via endoscopy are usually inadequate for establishing a definitive diagnosis. A case of a gastroesophageal junction primary HL is presented that was diagnosed on endoscopic biopsy material with the assistance of the immunohistochemical stains PAX5 and MUM1 which verified the presence of Reed-Sternberg cells. The patient was effectively treated for HL and avoided traditional laparotomy or thoracotomy procedures to obtain the diagnosis. This advanced immunohistochemical approach should be the standard in the diagnosis of primary gastrointestinal HL. An endoscopy-based approach should obviate more invasive, open biopsy procedures for establishing HL diagnosis. |
| format | Article |
| id | doaj-art-e31f1c231fb24e9fbefb028f80f3fd21 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-e31f1c231fb24e9fbefb028f80f3fd212025-02-03T01:12:00ZengWileyCanadian Journal of Gastroenterology0835-79002007-01-0121318518810.1155/2007/362360A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical AnalysisGarnet Horne0Shaun AC Medlicott1Adnan Mansoor2Johan Lategan3Raymond Lai4P Beck5Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, CanadaDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, CanadaDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, CanadaDepartment of Internal Medicine, Peter Lougheed Centre, University of Calgary, Calgary, CanadaCross Cancer Institute, University of Alberta, Edmonton, Alberta, CanadaDepartment of Internal Medicine, Peter Lougheed Centre, University of Calgary, Calgary, CanadaThe esophagus and stomach can be primary sites for Hodgkin lymphoma (HL). The pathognomonic feature of HL is the Reed-Sternberg cell. Because these cells can be rare in HL tumours, biopsies obtained via endoscopy are usually inadequate for establishing a definitive diagnosis. A case of a gastroesophageal junction primary HL is presented that was diagnosed on endoscopic biopsy material with the assistance of the immunohistochemical stains PAX5 and MUM1 which verified the presence of Reed-Sternberg cells. The patient was effectively treated for HL and avoided traditional laparotomy or thoracotomy procedures to obtain the diagnosis. This advanced immunohistochemical approach should be the standard in the diagnosis of primary gastrointestinal HL. An endoscopy-based approach should obviate more invasive, open biopsy procedures for establishing HL diagnosis.http://dx.doi.org/10.1155/2007/362360 |
| spellingShingle | Garnet Horne Shaun AC Medlicott Adnan Mansoor Johan Lategan Raymond Lai P Beck A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis Canadian Journal of Gastroenterology |
| title | A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis |
| title_full | A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis |
| title_fullStr | A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis |
| title_full_unstemmed | A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis |
| title_short | A Definitive Diagnosis of Primary Hodgkin Lymphoma on Endoscopic Biopsy Material Utilizing in-Depth Immunohistochemical Analysis |
| title_sort | definitive diagnosis of primary hodgkin lymphoma on endoscopic biopsy material utilizing in depth immunohistochemical analysis |
| url | http://dx.doi.org/10.1155/2007/362360 |
| work_keys_str_mv | AT garnethorne adefinitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT shaunacmedlicott adefinitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT adnanmansoor adefinitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT johanlategan adefinitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT raymondlai adefinitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT pbeck adefinitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT garnethorne definitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT shaunacmedlicott definitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT adnanmansoor definitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT johanlategan definitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT raymondlai definitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis AT pbeck definitivediagnosisofprimaryhodgkinlymphomaonendoscopicbiopsymaterialutilizingindepthimmunohistochemicalanalysis |