Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease
Objective. Emerging evidence demonstrates that vitamin D status contributes to the incidence of diabetic kidney disease (DKD). However, the causal relationships between vitamin D and mortality among individuals with DKD are inconclusive. Our study is aimed at exploring the relationship between serum...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9632355 |
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| _version_ | 1832553644521684992 |
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| author | Feng Xu Hongyu Lu Tianwen Lai Ling Lin Yongsong Chen |
| author_facet | Feng Xu Hongyu Lu Tianwen Lai Ling Lin Yongsong Chen |
| author_sort | Feng Xu |
| collection | DOAJ |
| description | Objective. Emerging evidence demonstrates that vitamin D status contributes to the incidence of diabetic kidney disease (DKD). However, the causal relationships between vitamin D and mortality among individuals with DKD are inconclusive. Our study is aimed at exploring the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and mortality among adults with DKD. Research Design and Methods. Our study included 1,202 adult participants with DKD from the National Health and Nutrition Examination Survey (NHANES) 2001–2014. Cox and competing-risks regression were used to estimate hazard ratios (HRs) and 95% CIs for associations between 25(OH)D concentrations and survival. Results. The overall mean serum 25(OH)D concentration was 55.9±26.3. Vitamin D deficiency (25OHD<50 nmol/l), insufficiency group (50≤25OHD<75 nmol/l), and sufficiency group (25OHD≥75 nmol/l) were observed in 552 (45.9%), 409 (34.0%), and 241 (20.0%) participants, respectively. Higher levels of vitamin D were significantly associated with improved all-cause and nonaccident- and malignant neoplasm-cause mortality among individuals with DKD after adjusting for the potential confounding factors. Conclusions. We observed widespread vitamin D deficiency or insufficiency in DKD patients. Higher 25(OH)D values were significantly correlated with lower risk of mortality after adjusting for confounding variables. |
| format | Article |
| id | doaj-art-e311cef4d8844ea28e706f5d5c9a2058 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e311cef4d8844ea28e706f5d5c9a20582025-02-03T05:53:33ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/9632355Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney DiseaseFeng Xu0Hongyu Lu1Tianwen Lai2Ling Lin3Yongsong Chen4Department of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineThe Affiliated Hospital of Guangdong Medical UniversityClinical Research CenterClinical Research CenterObjective. Emerging evidence demonstrates that vitamin D status contributes to the incidence of diabetic kidney disease (DKD). However, the causal relationships between vitamin D and mortality among individuals with DKD are inconclusive. Our study is aimed at exploring the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and mortality among adults with DKD. Research Design and Methods. Our study included 1,202 adult participants with DKD from the National Health and Nutrition Examination Survey (NHANES) 2001–2014. Cox and competing-risks regression were used to estimate hazard ratios (HRs) and 95% CIs for associations between 25(OH)D concentrations and survival. Results. The overall mean serum 25(OH)D concentration was 55.9±26.3. Vitamin D deficiency (25OHD<50 nmol/l), insufficiency group (50≤25OHD<75 nmol/l), and sufficiency group (25OHD≥75 nmol/l) were observed in 552 (45.9%), 409 (34.0%), and 241 (20.0%) participants, respectively. Higher levels of vitamin D were significantly associated with improved all-cause and nonaccident- and malignant neoplasm-cause mortality among individuals with DKD after adjusting for the potential confounding factors. Conclusions. We observed widespread vitamin D deficiency or insufficiency in DKD patients. Higher 25(OH)D values were significantly correlated with lower risk of mortality after adjusting for confounding variables.http://dx.doi.org/10.1155/2022/9632355 |
| spellingShingle | Feng Xu Hongyu Lu Tianwen Lai Ling Lin Yongsong Chen Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease Journal of Diabetes Research |
| title | Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease |
| title_full | Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease |
| title_fullStr | Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease |
| title_full_unstemmed | Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease |
| title_short | Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease |
| title_sort | association between vitamin d status and mortality among adults with diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2022/9632355 |
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