Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration
AIM: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. METHODS: Retrospective cohort analysis of anonymized data from participants aged 50y or more and d...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-01-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/1/20250112.pdf |
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| author | Inês Costa Ana Carvalho Helton Andrade Bruno Pereira Pedro Camacho |
| author_facet | Inês Costa Ana Carvalho Helton Andrade Bruno Pereira Pedro Camacho |
| author_sort | Inês Costa |
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| description | AIM: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. METHODS: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 participants were included from the Instituto de Retina de Lisboa (IRL) study (IPL/2022/MetAllAMD_ESTeSL) and divided into 4 groups according to the Rotterdam classification for AMD. Spectral domain optical coherence tomography (SD-OCT) was used to assess and quantify GCC and choroid thickness at two time points (first visit vs last visit) with a minimum interval of 3y. RESULTS: In the GCC inner ring, a thinner thickness (P=0.001) was observed in the atrophic AMD group (51.3±21.4 µm) compared to the early AMD (84.3±11.5 µm), intermediate AMD (77.6±16.1 µm) and neovascular AMD (88.9±16.3 µm) groups. Choroidal thickness quantification showed a generalized reduction in the central circle (P=0.002) and inner ring (P=0.001). Slight reductions in retinal thickness were more accentuated in the inner ring in the atrophic AMD (-13%; P<0.01). CONCLUSION: The variation of the analyzed structures could be an indicator of risk of progression with neurodegenerative (GCC) or vascular (choroid) pattern in the intermediate and atrophic AMD. The quantification of both structures can provide important information about the risk of disease progression in the early and intermediate stages but also for the evolution pattern into late stages (atrophic or neovascular). |
| format | Article |
| id | doaj-art-e30cfb8b2b3b40a686d5fafb73da59c0 |
| institution | OA Journals |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-e30cfb8b2b3b40a686d5fafb73da59c02025-08-20T01:57:55ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-01-0118110311010.18240/ijo.2025.01.1220250112Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degenerationInês Costa0Ana Carvalho1Helton Andrade2Bruno Pereira3Pedro Camacho4Pedro Camacho. ESTeSL–Escola Superior de Tecnologia da Saúde de Lisboa, Av. D. João II, Lote 4.69.01, Lisboa 1990-096, Portugal. pedro.camacho@estesl.ipl.ptEscola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Lisboa 1990-096, PortugalEscola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Lisboa 1990-096, PortugalH&TRC-Health & Technology Research Center, ESTeSL Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon 1990-096, Portugal; Instituto de Retina de Lisboa, IRL, Lisbon 1050-085, Portugal; iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon 1150-82, PortugalH&TRC-Health & Technology Research Center, ESTeSL Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon 1990-096, Portugal; Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Lisboa 1990-096, Portugal; iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon 1150-82, PortugalAIM: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. METHODS: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 participants were included from the Instituto de Retina de Lisboa (IRL) study (IPL/2022/MetAllAMD_ESTeSL) and divided into 4 groups according to the Rotterdam classification for AMD. Spectral domain optical coherence tomography (SD-OCT) was used to assess and quantify GCC and choroid thickness at two time points (first visit vs last visit) with a minimum interval of 3y. RESULTS: In the GCC inner ring, a thinner thickness (P=0.001) was observed in the atrophic AMD group (51.3±21.4 µm) compared to the early AMD (84.3±11.5 µm), intermediate AMD (77.6±16.1 µm) and neovascular AMD (88.9±16.3 µm) groups. Choroidal thickness quantification showed a generalized reduction in the central circle (P=0.002) and inner ring (P=0.001). Slight reductions in retinal thickness were more accentuated in the inner ring in the atrophic AMD (-13%; P<0.01). CONCLUSION: The variation of the analyzed structures could be an indicator of risk of progression with neurodegenerative (GCC) or vascular (choroid) pattern in the intermediate and atrophic AMD. The quantification of both structures can provide important information about the risk of disease progression in the early and intermediate stages but also for the evolution pattern into late stages (atrophic or neovascular).http://ies.ijo.cn/en_publish/2025/1/20250112.pdfage-related macular degenerationganglion cell complexchoroidgeographic atrophychoroidal neovascularizationspectral domain optical coherence tomography |
| spellingShingle | Inês Costa Ana Carvalho Helton Andrade Bruno Pereira Pedro Camacho Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration International Journal of Ophthalmology age-related macular degeneration ganglion cell complex choroid geographic atrophy choroidal neovascularization spectral domain optical coherence tomography |
| title | Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration |
| title_full | Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration |
| title_fullStr | Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration |
| title_full_unstemmed | Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration |
| title_short | Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration |
| title_sort | neurodegeneration and choroidal vascular features on oct in the progression to advanced age related macular degeneration |
| topic | age-related macular degeneration ganglion cell complex choroid geographic atrophy choroidal neovascularization spectral domain optical coherence tomography |
| url | http://ies.ijo.cn/en_publish/2025/1/20250112.pdf |
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