Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children
Allergic rhinitis (AR) is a public health problem with high prevalence worldwide. We evaluated levels of specific IgE, IgA, and IgG4 antibodies to the Dermatophagoides pteronyssinus (Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and non...
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/302739 |
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| author | Diego O. Miranda Deise A. O. Silva Jorge F. C. Fernandes Meimei G. J. Queirós Hamilton F. Chiba Leandro H. Ynoue Rafael O. Resende Janethe D. O. Pena Sun-Sang J. Sung Gesmar R. S. Segundo Ernesto A. Taketomi |
| author_facet | Diego O. Miranda Deise A. O. Silva Jorge F. C. Fernandes Meimei G. J. Queirós Hamilton F. Chiba Leandro H. Ynoue Rafael O. Resende Janethe D. O. Pena Sun-Sang J. Sung Gesmar R. S. Segundo Ernesto A. Taketomi |
| author_sort | Diego O. Miranda |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is a public health problem with high prevalence worldwide. We evaluated levels of specific IgE, IgA, and IgG4 antibodies to the Dermatophagoides pteronyssinus (Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and nonallergic children. A total of 86 children were analyzed, from which 72 had AR and 14 were nonallergic healthy children. Serum IgE and serum/salivary IgG4 levels to Dpt, Der p1, and Der p2 were higher in allergic children whereas serum/salivary IgA levels to all allergens were higher in nonallergic children. IgE levels positively correlated with IgG4 and IgA to all allergens in allergic children, while IgA levels negatively correlated with IgG4 to Dpt and Der p1 in nonallergic children. In conclusion, mite-specific IgA antibodies predominate in the serum and saliva of nonallergic children whereas mite-specific IgE and IgG4 are prevalent in allergic children. The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens. Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy. |
| format | Article |
| id | doaj-art-e309f4266be945659b7836b2a2f477b8 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e309f4266be945659b7836b2a2f477b82025-02-03T06:00:19ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/302739302739Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic ChildrenDiego O. Miranda0Deise A. O. Silva1Jorge F. C. Fernandes2Meimei G. J. Queirós3Hamilton F. Chiba4Leandro H. Ynoue5Rafael O. Resende6Janethe D. O. Pena7Sun-Sang J. Sung8Gesmar R. S. Segundo9Ernesto A. Taketomi10Laboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Clinical Analysis, 280 Padre Felix Street, 75523-220 Itumbiara, GO, BrazilLaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Molecular Biology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilCenter for Immunity, Inflammation and Regenerative Medicine, Department of Internal Medicine, Health Sciences Center, School of Medicine, University of Virginia, 22908-0395 Charlottesville, VA, USALaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilLaboratory of Allergy and Clinical Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, Campus Umuarama, 38400-902 Uberlândia, MG, BrazilAllergic rhinitis (AR) is a public health problem with high prevalence worldwide. We evaluated levels of specific IgE, IgA, and IgG4 antibodies to the Dermatophagoides pteronyssinus (Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and nonallergic children. A total of 86 children were analyzed, from which 72 had AR and 14 were nonallergic healthy children. Serum IgE and serum/salivary IgG4 levels to Dpt, Der p1, and Der p2 were higher in allergic children whereas serum/salivary IgA levels to all allergens were higher in nonallergic children. IgE levels positively correlated with IgG4 and IgA to all allergens in allergic children, while IgA levels negatively correlated with IgG4 to Dpt and Der p1 in nonallergic children. In conclusion, mite-specific IgA antibodies predominate in the serum and saliva of nonallergic children whereas mite-specific IgE and IgG4 are prevalent in allergic children. The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens. Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.http://dx.doi.org/10.1155/2011/302739 |
| spellingShingle | Diego O. Miranda Deise A. O. Silva Jorge F. C. Fernandes Meimei G. J. Queirós Hamilton F. Chiba Leandro H. Ynoue Rafael O. Resende Janethe D. O. Pena Sun-Sang J. Sung Gesmar R. S. Segundo Ernesto A. Taketomi Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children Clinical and Developmental Immunology |
| title | Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children |
| title_full | Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children |
| title_fullStr | Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children |
| title_full_unstemmed | Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children |
| title_short | Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children |
| title_sort | serum and salivary ige iga and igg4 antibodies to dermatophagoides pteronyssinus and its major allergens der p1 and der p2 in allergic and nonallergic children |
| url | http://dx.doi.org/10.1155/2011/302739 |
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